Diagnosis of Disseminated Toxoplasmosis by Bronchoalveolar Lavage PCR in a Patient with AIDS

Diagnosis of Disseminated Toxoplasmosis by Polymerase Chain Reaction in Bronchoalveolar Lavage Fluid of a Patient with AIDS

dc.creatorDora, Jose Miguel
dc.creatorGeib, Guilherme
dc.creatorde-Paris, Fernanda
dc.creatorMachado, Alice Beatriz
dc.creatorFurlanetto, Tania Weber
dc.creatorde Souza, Carolina Fischinger Moura
dc.creatordos Santos, Rodrigo Pires
dc.date2009-08-04
dc.identifierhttps://seer.ufrgs.br/index.php/hcpa/article/view/6937
dc.descriptionPulmonary toxoplasmosis is a challenging diagnosis in immunosuppressed patients with nonspecific clinical picture and radiologic findings. We present a case of pneumonia due to Toxoplasma gondii diagnosed by polymerase chain reaction (PCR) in the bronchoalveolar lavage (BAL) fluid of a patient with acquired immunodeficiency syndrome (AIDS). Coinfection with Pneumocystis jirovecii was found in the same specimen. Direct examination and culture for bacteria, mycobacteria and other fungus were negative. Despite the intensive management, respiratory compromise evolved rapidly, with the need for ventilatory support. Acute respiratory distress syndrome developed, and the patient died of multiple organ failure. This case illustrates that a high index of suspicion is necessary for diagnosis of pulmonary toxoplasmosis, a potentially fatal condition. Due to high diagnostic performance, PCR in BAL fluid should be included in the evaluation of immunosuppressed patients with nonspecific pulmonary diseases.  en-US
dc.descriptionPulmonary toxoplasmosis is a challenging diagnosis in immunosuppressed patients with nonspecific clinical picture and radiologic findings. We present a case of pneumonia due to Toxoplasma gondii diagnosed by polymerase chain reaction (PCR) in the bronchoalveolar lavage (BAL) fluid of a patient with acquired immunodeficiency syndrome (AIDS). Coinfection with Pneumocystis jirovecii was found in the same specimen. Direct examination and culture for bacteria, mycobacteria and other fungus were negative. Despite the intensive management, respiratory compromise evolved rapidly, with the need for ventilatory support. Acute respiratory distress syndrome developed, and the patient died of multiple organ failure. This case illustrates that a high index of suspicion is necessary for diagnosis of pulmonary toxoplasmosis, a potentially fatal condition. Due to high diagnostic performance, PCR in BAL fluid should be included in the evaluation of immunosuppressed patients with nonspecific pulmonary diseases.pt-BR
dc.formatapplication/pdf
dc.languagepor
dc.publisherHCPA/FAMED/UFRGSpt-BR
dc.relationhttps://seer.ufrgs.br/index.php/hcpa/article/view/6937/5817
dc.sourceClinical & Biomedical Research; Vol. 29 No. 2 (2009): Revista HCPAen-US
dc.sourceClinical and Biomedical Research; v. 29 n. 2 (2009): Revista HCPApt-BR
dc.source2357-9730
dc.subjectPCRen-US
dc.subjectHIVen-US
dc.subjectAIDSen-US
dc.subjecttoxoplasmosisen-US
dc.subjectdisseminated toxoplasmosisen-US
dc.subjectPCRpt-BR
dc.subjectHIVpt-BR
dc.subjectAIDSpt-BR
dc.subjecttoxoplasmosispt-BR
dc.subjectdisseminated toxoplasmosispt-BR
dc.titleDiagnosis of Disseminated Toxoplasmosis by Bronchoalveolar Lavage PCR in a Patient with AIDSen-US
dc.titleDiagnosis of Disseminated Toxoplasmosis by Polymerase Chain Reaction in Bronchoalveolar Lavage Fluid of a Patient with AIDSpt-BR
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typePeer-reviewed Articleen-US
dc.typeAvaliado por parespt-BR


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