Artículos de revistas
Anticonvulsant effect of sodium cyclamate and propylparaben on pentylenetetrazol-induced seizures in zebrafish
Fecha
2017-04Registro en:
Pisera Fuster, Antonella; Otero, Sofía; Talevi, Alan; Bruno Blanch, Luis Enrique; Bernabeu, Ramon Oscar; Anticonvulsant effect of sodium cyclamate and propylparaben on pentylenetetrazol-induced seizures in zebrafish; Wiley-liss, Div John Wiley & Sons Inc; Synapse; 71; 4; 4-2017; 1-10; e21961
0887-4476
CONICET Digital
CONICET
Autor
Pisera Fuster, Antonella
Otero, Sofía
Talevi, Alan
Bruno Blanch, Luis Enrique
Bernabeu, Ramon Oscar
Resumen
Screening for novel anticonvulsant drugs requires appropriate animal seizure models. Zebrafish provide small, accessible, and cost-efficient preclinical models applicable to high-throughput small molecule screening. Based on previous results in rodents, we have here examined the effects of artificial sweetener sodium cyclamate and antimicrobial agent sodium propylparaben on a model of pentylenetetrazole (PTZ)-induced seizures in zebrafish. Sodium cyclamate reduced the bursts of hyperactivity, the spasms, increased the latency to spasms, and the latency to seizure, while propylparaben increased the latency to spasms. The results show the potential of zebrafish to detect novel anticonvulsant compounds while they also demonstrate the ability of two commonly ingested chemical compounds to modify the seizure threshold when were administrated at low concentration.