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Computational and synthetic target-based approaches to the discovery of novel anticonvulsant compounds
(Bentham Science Publishers, 2021-05)
Background: During the past decades, an important number of anticonvulsant drugs have been incorporated into the collection of drugs to treat epilepsy. However, two main difficulties remain unsolved in therapy: the development ...
Prevalence of gingival hyperplasia induced by anticonvulsants: A systematic reviewPrevalência da hiperplasia gengival induzida pelo uso de anticonvulsivantes: Revisão sistemática
(2021-01-01)
Objective: Gingival hyperplasia (GH) is one of the side effects of anticonvulsant drugs. The aim of this study was to verify the prevalence of GH associated with the use of anticonvulsant, through a systematic review. ...
Nantenine alkaloid presents anticonvulsant effect on two classical animal models
(Urban & Fischer Verlag, 2003-01-01)
The present study investigated the anticonvulsant and convulsant profiles of nantenine, an aporphine alkaloid found in several vegetal species. At lower doses (20-50 mg/kg, i.p) the alkaloid proved to be effective in ...
Anticonvulsant effect of sodium cyclamate and propylparaben on pentylenetetrazol-induced seizures in zebrafish
(Wiley-liss, Div John Wiley & Sons Inc, 2017-04)
Screening for novel anticonvulsant drugs requires appropriate animal seizure models. Zebrafish provide small, accessible, and cost-efficient preclinical models applicable to high-throughput small molecule screening. Based ...
In vivo study of teratogenic and anticonvulsant effects of antiepileptics drugs in zebrafish embryo and larvae
(Pergamon-Elsevier Science Ltd, 2018-03)
Epilepsy is a neurological disorder treated with antiepileptic drugs (AEDs). Since AEDs are administered in women in childbearing age, it is critical to study if drugs are capable of inducing developmental toxicity. Along ...