Artículos de revistas
Syntheses of 3,4- and 1,4-dihydroquinazolines from 2-aminobenzylamine
Fecha
2017-06Registro en:
Díaz, Jimena Estela; Ranieri, Silvia; Gruber, Nadia; Orelli, Liliana Raquel; Syntheses of 3,4- and 1,4-dihydroquinazolines from 2-aminobenzylamine; Beilstein-Institut; Beilstein Journal Of Organic Chemistry; 13; 6-2017; 1470-1477
1860-5397
CONICET Digital
CONICET
Autor
Díaz, Jimena Estela
Ranieri, Silvia
Gruber, Nadia
Orelli, Liliana Raquel
Resumen
A straightforward strategy for the synthesis of dihydroquinazolines is presented, which allows for the preparation of 3,4- and 1,4-dihydroquinazolines with different substitution patterns from 2-aminobenzylamine (2-ABA) as common precursor. The required functionalization of both amino groups present in 2-ABA was achieved by different routes involving selective N-acylation and cesium carbonate mediated N-alkylation reactions, avoiding protection/deprotection steps. The heterocycles were efficiently synthesized in short reaction times by microwave-assisted ring closure of the corresponding aminoamides promoted by ethyl polyphosphate (PPE).