info:eu-repo/semantics/article
Diazepam treatment reduces inflammatory cells and mediators in the central nervous system of rats with experimental autoimmune encephalomyelitis
Fecha
2017-12Registro en:
Fernández Hurst, Nicolás; Zanetti, Samanta Romina; Baez, Natalia Soledad; Bibolini, Mario Javier; Bouzat, Cecilia Beatriz; et al.; Diazepam treatment reduces inflammatory cells and mediators in the central nervous system of rats with experimental autoimmune encephalomyelitis; Elsevier Science; Journal of Neuroimmunology; 313; 12-2017; 145-151
0165-5728
CONICET Digital
CONICET
Autor
Fernández Hurst, Nicolás
Zanetti, Samanta Romina
Baez, Natalia Soledad
Bibolini, Mario Javier
Bouzat, Cecilia Beatriz
Roth, German Alfredo
Resumen
Benzodiazepines are psychoactive drugs and some of them also affect immune cells. We here characterized the inflammatory and infiltrating immune cells in the central nervous system (CNS) during the acute phase of experimental autoimmune encephalomyelitis (EAE) in animals treated with Diazepam. Also, we evaluated the expression of Translocator Protein (18kDa) (TSPO), which is a biomarker of neuroinflammatory diseases. The results indicate that Diazepam exerts protective effects on EAE development, decreasing the incidence of the disease and reducing the number of inflammatory cells in CNS, with a concomitant decrease of TSPO levels in brain tissue and CNS inflammatory CD11b+ cells.