Diazepam treatment reduces inflammatory cells and mediators in the central nervous system of rats with experimental autoimmune encephalomyelitis

dc.creatorFernández Hurst, Nicolás
dc.creatorZanetti, Samanta Romina
dc.creatorBaez, Natalia Soledad
dc.creatorBibolini, Mario Javier
dc.creatorBouzat, Cecilia Beatriz
dc.creatorRoth, German Alfredo
dc.date.accessioned2018-04-05T23:40:04Z
dc.date.available2018-04-05T23:40:04Z
dc.date.created2018-04-05T23:40:04Z
dc.date.issued2017-12
dc.identifierFernández Hurst, Nicolás; Zanetti, Samanta Romina; Baez, Natalia Soledad; Bibolini, Mario Javier; Bouzat, Cecilia Beatriz; et al.; Diazepam treatment reduces inflammatory cells and mediators in the central nervous system of rats with experimental autoimmune encephalomyelitis; Elsevier Science; Journal of Neuroimmunology; 313; 12-2017; 145-151
dc.identifier0165-5728
dc.identifierhttp://hdl.handle.net/11336/41033
dc.identifierCONICET Digital
dc.identifierCONICET
dc.description.abstractBenzodiazepines are psychoactive drugs and some of them also affect immune cells. We here characterized the inflammatory and infiltrating immune cells in the central nervous system (CNS) during the acute phase of experimental autoimmune encephalomyelitis (EAE) in animals treated with Diazepam. Also, we evaluated the expression of Translocator Protein (18kDa) (TSPO), which is a biomarker of neuroinflammatory diseases. The results indicate that Diazepam exerts protective effects on EAE development, decreasing the incidence of the disease and reducing the number of inflammatory cells in CNS, with a concomitant decrease of TSPO levels in brain tissue and CNS inflammatory CD11b+ cells.
dc.languageeng
dc.publisherElsevier Science
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.jni-journal.com/article/S0165-5728(17)30297-7/fulltext
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.jneuroim.2017.09.012
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAutoimmunity
dc.subjectDiazepam
dc.subjectInflammatory T Cells
dc.subjectTspo
dc.titleDiazepam treatment reduces inflammatory cells and mediators in the central nervous system of rats with experimental autoimmune encephalomyelitis
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:ar-repo/semantics/artículo
dc.typeinfo:eu-repo/semantics/publishedVersion


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