Artículos de revistas
Chemoenzymatic synthesis of fluoxetine precursors. Reduction of β-substituted propiophenones
Fecha
2014-02-07Registro en:
Coronel, Camila Denise; Arce, Gabriel; Iglesias, Cesar; Magallanes Noguera, Cynthia Alejandra; Rodriguez Bonnecarrere, Paula; et al.; Chemoenzymatic synthesis of fluoxetine precursors. Reduction of β-substituted propiophenones; Elsevier; Journal of Molecular Catalysis B: Enzymatic; 102; 7-2-2014; 94-98
1381-1177
Autor
Coronel, Camila Denise
Arce, Gabriel
Iglesias, Cesar
Magallanes Noguera, Cynthia Alejandra
Rodriguez Bonnecarrere, Paula
Rodriguez Giordano, Sonia
Gonzales, David
Resumen
Five endophytic yeast strains isolated from edible plants were tested in the reduction β-chloro- and β-azidopropiophenone for the preparation of optically active fluoxetine precursors. The biotransformation rendered not only the corresponding chiral γ-substituted alcohols, but also unsubstituted alcohols and ketones. The product profile was studied and a plausible mechanism for the reductive elimination of the β-functional group is proposed.