Chemoenzymatic synthesis of fluoxetine precursors. Reduction of β-substituted propiophenones

dc.creatorCoronel, Camila Denise
dc.creatorArce, Gabriel
dc.creatorIglesias, Cesar
dc.creatorMagallanes Noguera, Cynthia Alejandra
dc.creatorRodriguez Bonnecarrere, Paula
dc.creatorRodriguez Giordano, Sonia
dc.creatorGonzales, David
dc.date.accessioned2016-05-24T18:54:43Z
dc.date.accessioned2018-11-06T13:27:49Z
dc.date.available2016-05-24T18:54:43Z
dc.date.available2018-11-06T13:27:49Z
dc.date.created2016-05-24T18:54:43Z
dc.date.issued2014-02-07
dc.identifierCoronel, Camila Denise; Arce, Gabriel; Iglesias, Cesar; Magallanes Noguera, Cynthia Alejandra; Rodriguez Bonnecarrere, Paula; et al.; Chemoenzymatic synthesis of fluoxetine precursors. Reduction of β-substituted propiophenones; Elsevier; Journal of Molecular Catalysis B: Enzymatic; 102; 7-2-2014; 94-98
dc.identifier1381-1177
dc.identifierhttp://hdl.handle.net/11336/5815
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1875613
dc.description.abstractFive endophytic yeast strains isolated from edible plants were tested in the reduction β-chloro- and β-azidopropiophenone for the preparation of optically active fluoxetine precursors. The biotransformation rendered not only the corresponding chiral γ-substituted alcohols, but also unsubstituted alcohols and ketones. The product profile was studied and a plausible mechanism for the reductive elimination of the β-functional group is proposed.
dc.languageeng
dc.publisherElsevier
dc.relationinfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1381117714000332
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.molcatb.2014.01.022
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.molcatb.2014.01.022
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectENDOPHYTES
dc.subjectFLUOXETINE
dc.subjectB-SUBSTITUTED KETONE
dc.titleChemoenzymatic synthesis of fluoxetine precursors. Reduction of β-substituted propiophenones
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución