dc.creator | Coronel, Camila Denise | |
dc.creator | Arce, Gabriel | |
dc.creator | Iglesias, Cesar | |
dc.creator | Magallanes Noguera, Cynthia Alejandra | |
dc.creator | Rodriguez Bonnecarrere, Paula | |
dc.creator | Rodriguez Giordano, Sonia | |
dc.creator | Gonzales, David | |
dc.date.accessioned | 2016-05-24T18:54:43Z | |
dc.date.accessioned | 2018-11-06T13:27:49Z | |
dc.date.available | 2016-05-24T18:54:43Z | |
dc.date.available | 2018-11-06T13:27:49Z | |
dc.date.created | 2016-05-24T18:54:43Z | |
dc.date.issued | 2014-02-07 | |
dc.identifier | Coronel, Camila Denise; Arce, Gabriel; Iglesias, Cesar; Magallanes Noguera, Cynthia Alejandra; Rodriguez Bonnecarrere, Paula; et al.; Chemoenzymatic synthesis of fluoxetine precursors. Reduction of β-substituted propiophenones; Elsevier; Journal of Molecular Catalysis B: Enzymatic; 102; 7-2-2014; 94-98 | |
dc.identifier | 1381-1177 | |
dc.identifier | http://hdl.handle.net/11336/5815 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1875613 | |
dc.description.abstract | Five endophytic yeast strains isolated from edible plants were tested in the reduction β-chloro- and β-azidopropiophenone for the preparation of optically active fluoxetine precursors. The biotransformation rendered not only the corresponding chiral γ-substituted alcohols, but also unsubstituted alcohols and ketones. The product profile was studied and a plausible mechanism for the reductive elimination of the β-functional group is proposed. | |
dc.language | eng | |
dc.publisher | Elsevier | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S1381117714000332 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1016/j.molcatb.2014.01.022 | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/10.1016/j.molcatb.2014.01.022 | |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.subject | ENDOPHYTES | |
dc.subject | FLUOXETINE | |
dc.subject | B-SUBSTITUTED KETONE | |
dc.title | Chemoenzymatic synthesis of fluoxetine precursors. Reduction of β-substituted propiophenones | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |
dc.type | Artículos de revistas | |