Ruthenium-Catalyzed Peri- and Ortho-Alkynylation with Bromoalkynes via Insertion and Elimination

Tan, Eric; Konovalov, Andrey I.; Fernandez, Gabriela Araceli; Dorel, Ruth; Echavarren, Antonio M.

Artículos de revistas

Fecha

2017-10

Registro en:

Tan, Eric; Konovalov, Andrey I.; Fernandez, Gabriela Araceli; Dorel, Ruth; Echavarren, Antonio M.; Ruthenium-Catalyzed Peri- and Ortho-Alkynylation with Bromoalkynes via Insertion and Elimination; American Chemical Society; Organic Letters; 19; 20; 10-2017; 5561-5564

1523-7060

http://hdl.handle.net/11336/50324

CONICET Digital

CONICET

http://repositorioslatinoamericanos.uchile.cl/handle/2250/1871239

Autor

Tan, Eric

Konovalov, Andrey I.

Fernandez, Gabriela Araceli

Dorel, Ruth

Echavarren, Antonio M.

Institución

Consejo Nacional de Investigaciones Científicas y Tecnológicas (Argentina)

Resumen

The alkynylation of naphthols takes place with total regiocontrol at the peri position of the hydroxyl group in the presence of [RuCl2(p-cymene)]2 as the catalyst. This reaction features high functional group tolerance. The related ortho-alkynylation of benzoic acids proceeds under similar conditions and also shows wide functional group tolerance. Both reactions proceed through metalation, insertion of the alkyne, and bromide elimination.

Materias

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