Artículos de revistas
Pharmacotherapy with 17β-estradiol and progesterone prevents development of mouse experimental autoimmune encephalomyelitis
Fecha
2010-01-01Registro en:
Garay, Laura Ines; Gonzalez Deniselle, Maria Claudia; Gierman, Lobke; Lima, Analia Ethel; Roig, Paulina; et al.; Pharmacotherapy with 17β-estradiol and progesterone prevents development of mouse experimental autoimmune encephalomyelitis; De Gruyter; Hormone Molecular Biology and Clinical Investigation; 1; 1; 1-1-2010; 43-51
1868-1883
1868-1891
Autor
Garay, Laura Ines
Gonzalez Deniselle, Maria Claudia
Gierman, Lobke
Lima, Analia Ethel
Roig, Paulina
de Nicola, Alejandro Federico
Resumen
Pregnant women with multiple sclerosis (MS) show disease remission in the third trimester concomitant with high circulating levels of sex steroids. Rodent experimental autoimmune encephalomyelitis (EAE) is an accepted model for MS. Previous studies have shown that monotherapy with estrogens or progesterone exert beneficial effects on EAE. The aim of the present study was to determine if estrogen and progesterone cotherapy of C57BL/6 female mice provided substantial protection from EAE.