Artículos de revistas
Swainsonine-induced lysosomal storage disease in goats caused by the ingestion of Sida rodrigoi Monteiro in North-western Argentina
Fecha
2017-03Registro en:
Micheloud, Juan Francisco; Marin, Raúl; Colque Caro, Luis Adrián; Martinez, Olga Gladys; Gardner, Dale; et al.; Swainsonine-induced lysosomal storage disease in goats caused by the ingestion of Sida rodrigoi Monteiro in North-western Argentina; Pergamon-Elsevier Science Ltd; Toxicon; 128; 3-2017; 1-4
0041-0101
CONICET Digital
CONICET
Autor
Micheloud, Juan Francisco
Marin, Raúl
Colque Caro, Luis Adrián
Martinez, Olga Gladys
Gardner, Dale
Gimeno, Eduardo Juan
Resumen
There are numerous poisonous plants that can induce intralysosomal accumulation of glycoproteins and neurologic syndromes. Here we describe for the first time, a disease caused by ingesting Sida rodrigoi Monteiro in goats in North-western Argentina. The animals showed weight loss, indifference to the environment, unsteady gait and ataxia. Histopathologic studies showed vacuolization in cells of various organs, mainly in the CNS. The material deposited in the cells was positive for LCA (Lens culinaris agglutinin), WGA (Triticum vulgaris agglutinin), sWGA (succinyl-Triticum vulgaris agglutinin) and Con-A (Concanavalia ensiformis agglutinin) lectins. Finally, toxic levels of swansonine were identified in the plant. The present investigation allowed to recognize S. rodrigoi Monteiro poisoning as a plant induced α-mannosidosis.