Swainsonine-induced lysosomal storage disease in goats caused by the ingestion of Sida rodrigoi Monteiro in North-western Argentina

dc.creatorMicheloud, Juan Francisco
dc.creatorMarin, Raúl
dc.creatorColque Caro, Luis Adrián
dc.creatorMartinez, Olga Gladys
dc.creatorGardner, Dale
dc.creatorGimeno, Eduardo Juan
dc.date.accessioned2018-08-13T17:50:23Z
dc.date.accessioned2018-11-06T12:04:00Z
dc.date.available2018-08-13T17:50:23Z
dc.date.available2018-11-06T12:04:00Z
dc.date.created2018-08-13T17:50:23Z
dc.date.issued2017-03
dc.identifierMicheloud, Juan Francisco; Marin, Raúl; Colque Caro, Luis Adrián; Martinez, Olga Gladys; Gardner, Dale; et al.; Swainsonine-induced lysosomal storage disease in goats caused by the ingestion of Sida rodrigoi Monteiro in North-western Argentina; Pergamon-Elsevier Science Ltd; Toxicon; 128; 3-2017; 1-4
dc.identifier0041-0101
dc.identifierhttp://hdl.handle.net/11336/55156
dc.identifierCONICET Digital
dc.identifierCONICET
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1862737
dc.description.abstractThere are numerous poisonous plants that can induce intralysosomal accumulation of glycoproteins and neurologic syndromes. Here we describe for the first time, a disease caused by ingesting Sida rodrigoi Monteiro in goats in North-western Argentina. The animals showed weight loss, indifference to the environment, unsteady gait and ataxia. Histopathologic studies showed vacuolization in cells of various organs, mainly in the CNS. The material deposited in the cells was positive for LCA (Lens culinaris agglutinin), WGA (Triticum vulgaris agglutinin), sWGA (succinyl-Triticum vulgaris agglutinin) and Con-A (Concanavalia ensiformis agglutinin) lectins. Finally, toxic levels of swansonine were identified in the plant. The present investigation allowed to recognize S. rodrigoi Monteiro poisoning as a plant induced α-mannosidosis.
dc.languageeng
dc.publisherPergamon-Elsevier Science Ltd
dc.relationinfo:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.toxicon.2016.12.011
dc.relationinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0041010116306316
dc.rightshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectARGENTINIAN NORTHEASTERN
dc.subjectPOISONOUS PLANTS
dc.subjectSTORAGE DISEASE
dc.subjectSWAINSONINE
dc.titleSwainsonine-induced lysosomal storage disease in goats caused by the ingestion of Sida rodrigoi Monteiro in North-western Argentina
dc.typeArtículos de revistas
dc.typeArtículos de revistas
dc.typeArtículos de revistas


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