dc.date.accessioned2018-10-01T20:22:23Z
dc.date.available2018-10-01T20:22:23Z
dc.date.created2018-10-01T20:22:23Z
dc.date.issued2015
dc.identifierhttp://hdl.handle.net/10533/220743
dc.identifier1140011
dc.identifierWOS:000349512100010
dc.description.abstractHerpes simplex viruses and humans have co-existed for tens of thousands of years. This long relationship has translated into the evolution and selection of viral determinants to evade the host immune response and reciprocally the evolution and selection of host immune components for limiting virus infection and damage. Currently there are no vaccines available to avoid infection with these viruses or therapies to cure them. Herpes simplex viruses are neurotropic and reside latently in neurons at the trigeminal and dorsal root ganglia, occasionally reactivating. Most viral recurrences are subclinical and thus, unnoticed. Here, we discuss the initial steps of infection by herpes simplex viruses and the molecular mechanisms they have developed to evade innate and adaptive immunity. A better understanding of the molecular mechanisms evolved by these viruses to evade host immunity should help us envision novel vaccine strategies and therapies that limit infection and dissemination. Keywords. Author Keywords:Genital infection; innate immune evasion; adaptive immune evasion; latency; reactivation . KeyWords Plus:DOUBLE-STRANDED-RNA; SEXUALLY-TRANSMITTED-DISEASES; DEPENDENT PROTEIN-KINASE; RECURRENT GENITAL HERPES; VARICELLA-ZOSTER-VIRUS; HUMAN DENDRITIC CELLS; NATURAL-KILLER-CELLS; NF-KAPPA-B; T-CELLS; GLYCOPROTEIN-D
dc.languageeng
dc.relationhttps://www.ncbi.nlm.nih.gov/pubmed/25860047
dc.relation10.4067/S0716-10182015000200009
dc.relationinfo:eu-repo/grantAgreement//1140011
dc.relationinfo:eu-repo/semantics/dataset/hdl.handle.net/10533/93477
dc.relationinstname: Conicyt
dc.relationreponame: Repositorio Digital RI2.0
dc.rightshttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile
dc.titleImmune evasion by herpes simplex viruses
dc.typeArticulo


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