Artículos de revistas
Theophylline is able to partially revert cachexia in tumour-bearing rats
Fecha
2012-08-21Registro en:
Nutrition & Metabolism. 2012 Aug 21;9(1):76
Autor
Olivan, Mireia
Springer, Jochen
Busquets, Sílvia
Tschirner, Anika
Figueras, Maite
Toledo, Miriam
Fontes-Oliveira, Cibely
Genovese, Maria I
Ventura da Silva, Paula
Sette, Angelica
López-Soriano, Francisco J
Anker, Stefan
Argilés, Josep M
Institución
Resumen
Abstract
Background and aims
The aim of the present investigation was to examine the anti-wasting effects of theophylline (a methylxantine present in tea leaves) on a rat model of cancer cachexia.
Methods
The in vitro effects of the nutraceuticals on proteolysis were examined on muscle cell cultures submitted to hyperthermia. Individual muscle weights, muscle gene expression, body composition and cardiac function were measured in rats bearing the Yoshida AH-130 ascites hepatoma, following theophylline treatment.
Results
Theophylline treatment inhibited proteolysis in C2C12 cell line and resulted in an anti-proteolytic effect on muscle tissue (soleus and heart), which was associated with a decrease in circulating TNF-alpha levels and with a decreased proteolytic systems gene expression. Treatment with the nutraceutical also resulted in an improvement in body composition and cardiac function.
Conclusion
Theophylline - alone or in combination with drugs - may be a candidate molecule for the treatment of cancer cachexia.