Theophylline is able to partially revert cachexia in tumour-bearing rats

dc.creatorOlivan, Mireia
dc.creatorSpringer, Jochen
dc.creatorBusquets, Sílvia
dc.creatorTschirner, Anika
dc.creatorFigueras, Maite
dc.creatorToledo, Miriam
dc.creatorFontes-Oliveira, Cibely
dc.creatorGenovese, Maria I
dc.creatorVentura da Silva, Paula
dc.creatorSette, Angelica
dc.creatorLópez-Soriano, Francisco J
dc.creatorAnker, Stefan
dc.creatorArgilés, Josep M
dc.date.accessioned2015-02-09T14:43:01Z
dc.date.accessioned2018-07-04T17:02:07Z
dc.date.available2015-02-09T14:43:01Z
dc.date.available2018-07-04T17:02:07Z
dc.date.created2015-02-09T14:43:01Z
dc.date.issued2012-08-21
dc.identifierNutrition & Metabolism. 2012 Aug 21;9(1):76
dc.identifierhttp://dx.doi.org/10.1186/1743-7075-9-76
dc.identifierhttp://www.producao.usp.br/handle/BDPI/48079
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1643752
dc.description.abstractAbstract Background and aims The aim of the present investigation was to examine the anti-wasting effects of theophylline (a methylxantine present in tea leaves) on a rat model of cancer cachexia. Methods The in vitro effects of the nutraceuticals on proteolysis were examined on muscle cell cultures submitted to hyperthermia. Individual muscle weights, muscle gene expression, body composition and cardiac function were measured in rats bearing the Yoshida AH-130 ascites hepatoma, following theophylline treatment. Results Theophylline treatment inhibited proteolysis in C2C12 cell line and resulted in an anti-proteolytic effect on muscle tissue (soleus and heart), which was associated with a decrease in circulating TNF-alpha levels and with a decreased proteolytic systems gene expression. Treatment with the nutraceutical also resulted in an improvement in body composition and cardiac function. Conclusion Theophylline - alone or in combination with drugs - may be a candidate molecule for the treatment of cancer cachexia.
dc.languageen
dc.rightsOlivan et al.; licensee BioMed Central Ltd.
dc.titleTheophylline is able to partially revert cachexia in tumour-bearing rats
dc.typeArtículos de revistas


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