Artículos de revistas
Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling
Fecha
2013Registro en:
Journal of Otolaryngology - Head and Neck Surgery, London, v.42, p.1-5, 2013
1916-0216
10.1186/1916-0216-42-27
Autor
Pezato, Rogério
Balsalobre, Leonardo
Lima, Milena
Bezerra, Thiago Freire Pinto
Voegels, Richard Louis
Gregório, Luis Carlos
Stamm, Aldo Cassol
Zele, Thibaut van
Institución
Resumen
This review is addressed two pathophysiologic mechanisms implicated in the pathogenesis of nasal polyposis: the unique remodeling process found in nasal polyp tissue and the immune response of patients with nasal polyposis to Staphylococcus aureus.
These two theories converge to the same direction in different aspects, including decreased extracellular matrix production, impaired T regulation and favoring of a Th2 immune response.
In patients with nasal polyposis, an exaggerated immune response to Staphylococcus aureus may aggravate the airway remodeling process.