Convergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling

dc.creatorPezato, Rogério 
dc.creatorBalsalobre, Leonardo 
dc.creatorLima, Milena 
dc.creatorBezerra, Thiago Freire Pinto
dc.creatorVoegels, Richard Louis
dc.creatorGregório, Luis Carlos 
dc.creatorStamm, Aldo Cassol 
dc.creatorZele, Thibaut van 
dc.date.accessioned2013-10-14T17:56:14Z
dc.date.accessioned2018-07-04T16:30:48Z
dc.date.available2013-10-14T17:56:14Z
dc.date.available2018-07-04T16:30:48Z
dc.date.created2013-10-14T17:56:14Z
dc.date.issued2013
dc.identifierJournal of Otolaryngology - Head and Neck Surgery, London, v.42, p.1-5, 2013
dc.identifier1916-0216
dc.identifierhttp://www.producao.usp.br/handle/BDPI/34989
dc.identifierhttp://dx.doi.org/10.1186/1916-0216-42-27
dc.identifier10.1186/1916-0216-42-27
dc.identifierhttp://www.journalotohns.com/content/42/1/27
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1636619
dc.description.abstractThis review is addressed two pathophysiologic mechanisms implicated in the pathogenesis of nasal polyposis: the unique remodeling process found in nasal polyp tissue and the immune response of patients with nasal polyposis to Staphylococcus aureus. These two theories converge to the same direction in different aspects, including decreased extracellular matrix production, impaired T regulation and favoring of a Th2 immune response. In patients with nasal polyposis, an exaggerated immune response to Staphylococcus aureus may aggravate the airway remodeling process.
dc.languageeng
dc.publisherBioMed Central
dc.publisherLondon
dc.relationJournal of Otolaryngology - Head and Neck Surgery
dc.rightsPezato et al.; licensee BioMed Central Ltd. - This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
dc.rightsopenAccess
dc.subjectAirway remodeling
dc.subjectSuperantigens
dc.subjectNasal polyps
dc.titleConvergence of two major pathophysiologic mechanisms in nasal polyposis: immune response to Staphylococcus aureus and airway remodeling
dc.typeArtículos de revistas


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