Artículos de revistas
Effects of voluntary running on spatial memory and mature brain-derived neurotrophic factor expression in mice hippocampus after status epilepticus
Fecha
2009Registro en:
BEHAVIOURAL BRAIN RESEARCH, v.203, n.2, p.165-172, 2009
0166-4328
10.1016/j.bbr.2009.04.022
Autor
SARTORI, Cesar Renato
PELAGIO, Fernanda Campos
TEIXEIRA, Simone Aparecida
VALENTINUZZI, Veronica Sandra
NASCIMENTO, Andre Luiz
ROGERIO, Fabio
MUSCARA, Marcelo Nicolas
FERRARI, Elenice Aparecida de Moraes
LANGONE, Francesco
Institución
Resumen
Voluntary physical activity improves memory and learning ability in rodents, whereas status epilepticus has been associated with memory impairment. Physical activity and seizures have been associated with enhanced hippocampal expression of BDNF, indicating that this protein may have a dual role in epilepsy. The influence of voluntary physical activity on memory and BDNF expression has been poorly studied in experimental models of epilepsy. In this paper, we have investigated the effect of voluntary physical activity on memory and BDNF expression in mice with pilocarpine-incluced epilepsy. Male Swiss mice were assigned to four experimental groups: pilocarpine sedentary (PS), pilocarpine runners (PRs), saline sedentary (SS) and saline runners (SRs). Two days after pilocarpine-induced status epilepticus, the affected mice (PR) and their running controls (SR) were housed with access to a running wheel for 28 days. After that, the spatial memory and the expression of the precursor and mature forms of hippocampal BDNF were assessed. PR mice performed better than PS mice in the water maze test. In addition, PR mice had a higher amount of mature BDNF (14 kDa) relative to the total BDNF (14 kDa + 28 kDa + 32 kDa forms) content when compared with PS mice. These results show that voluntary physical activity improved the spatial memory and increased the hippocampal content of mature BDNF of mice with pilocarpine-induced status epilepticus. (C) 2009 Elsevier B.V. All rights reserved.