Artículos de revistas
Negative Anti-C1q Antibody Titers May Influence Therapeutic Decisions and Reduce the Number of Renal Biopsies in Systemic Lupus Erythematosus
Fecha
2011Registro en:
NEPHRON CLINICAL PRACTICE, v.118, n.4, p.C355-C360, 2011
1660-2110
10.1159/000323388
Autor
MOURA, Carlos Geraldo Guerreiro de
MANGUEIRA, Cristovao Luis Pitangueira
CRUZ, Luzia Arlinda Sampaio
CRUZ, Constanca Margarida Sampaio
Institución
Resumen
In a cross-sectional study involving 62 patients with systemic lupus erythematosus (SLE), we found that patients with biopsy-proven lupus nephritis (LN) had higher titers of anti-C1q antibodies than active SLE without nephritis patients. Anti-C1q was associated with a negative predictive value of 94.59%, a positive predictive value of 52%, a sensitivity of 86.66% and a specificity of 74.47% for the diagnosis of LN. We conclude that high titers of anti-C1q antibodies are strongly associated with the presence of active LN, and the negative predictive value of this test for diagnosing LN is very high; therefore, it can influence therapeutic decisions and reduce the number of renal biopsies in patients with SLE. Copyright (C) 2011 S. Karger AG, Basel