Artículos de revistas
Bioreduction of substituted a-tetralones promoted by Daucus carota root
Química Nova, v.31, n.4, p.813-817, 2008
FERRAZ, Helena M. C.
BIANCO, Graziela G.
BOMBONATO, Fernanda I.
ANDRADE, Leandro H.
PORTO, André L. M.
The bioreduction of a series of substituted a-tetralones, carried out using Daucus carota root (carrot), afforded the corresponding homochiral a-tetralols in variable conversions (9 to 90%) and excellent enantiomeric excesses. Two of the assayed a-tetralones were resistant to the bioreduction conditions. The absolute configurations of four a-tetralols were assigned as being (S), by comparison to the (S)-enantiomers obtained by kinetic resolution promoted by CALB-catalysed acetylation. Additionally, the new 5-methoxy-6-methyl-1-tetralone was synthesized in seven steps from 3-methylsalicylic acid.