Bioreduction of substituted a-tetralones promoted by Daucus carota root

dc.creatorFERRAZ, Helena M. C.
dc.creatorBIANCO, Graziela G.
dc.creatorBOMBONATO, Fernanda I.
dc.creatorANDRADE, Leandro H.
dc.creatorPORTO, André L. M.
dc.date.accessioned2012-03-26T22:39:57Z
dc.date.accessioned2018-07-04T14:26:22Z
dc.date.available2012-03-26T22:39:57Z
dc.date.available2018-07-04T14:26:22Z
dc.date.created2012-03-26T22:39:57Z
dc.date.issued2008
dc.identifierQuímica Nova, v.31, n.4, p.813-817, 2008
dc.identifier0100-4042
dc.identifierhttp://producao.usp.br/handle/BDPI/12317
dc.identifier10.1590/S0100-40422008000400020
dc.identifierhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000400020
dc.identifierhttp://www.scielo.br/pdf/qn/v31n4/a20v31n4.pdf
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1610084
dc.description.abstractThe bioreduction of a series of substituted a-tetralones, carried out using Daucus carota root (carrot), afforded the corresponding homochiral a-tetralols in variable conversions (9 to 90%) and excellent enantiomeric excesses. Two of the assayed a-tetralones were resistant to the bioreduction conditions. The absolute configurations of four a-tetralols were assigned as being (S), by comparison to the (S)-enantiomers obtained by kinetic resolution promoted by CALB-catalysed acetylation. Additionally, the new 5-methoxy-6-methyl-1-tetralone was synthesized in seven steps from 3-methylsalicylic acid.
dc.languageeng
dc.publisherSociedade Brasileira de Química
dc.relationQuímica Nova
dc.rightsCopyright Sociedade Brasileira de Química
dc.rightsopenAccess
dc.subjectBioreduction
dc.subjectDaucus carota
dc.subject<FONT FACE=Symbol>a</font>-tetralols
dc.titleBioreduction of substituted a-tetralones promoted by Daucus carota root
dc.typeArtículos de revistas


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