Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)In this paper a mixed integer set resulting from the intersection of a single constrained mixed 0-1 set with the vertex packing set is investigated. This set arises as a subproblem of more general mixed integer problems such as inventory routing and facility location problems. Families of strong valid inequalities that take into account the structure of the simple mixed integer set and that of the vertex packing set simultaneously are introduced. In particular, the well-known mixed integer rounding inequality is generalized to the case where incompatibilities between binary variables are present. Exact and heuristic algorithms are designed to solve the separation problems associated to the proposed valid inequalities. Preliminary computational experiments show that these inequalities can be useful to reduce the integrality gaps and to solve integer programming problems. (C) 2016 Elsevier B.V. All rights reserved.214270CAPES/FCT from the Brazilian Ministry of EducationPortuguese Foundation for Science and Technology (FCT)FCT [EXPL/MAT-NAN/1761/2013, FCOMP-01-0124-FEDER-041898, UID/MAT/04106/2013]CNPq from the Brazilian Ministry of Science, Technology and Innovation [304727/2014-8, 477692/2012-5]Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)