Artículos de revistas
Relationship Between The Iga Antibody Response Against Streptococcus Mutans Gbpb And Severity Of Dental Caries In Childhood
Registro en:
1879-1506
Archives Of Oral Biology. PERGAMON-ELSEVIER SCIENCE LTD, n. 67, p. 22 - 27.
0003-9969
WOS:000375508400004
10.1016/j.archoralbio.2016.03.006
Autor
Colombo
NH; Pereira
JA; da Silva
MER; Ribas
LFF; Parisotto
TM; Mattos-Graner
RD; Smith
DJ; Duque
C
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Objective: Explore the associations between the severity of dental caries in childhood, mutans streptococci (MS) levels and IgA antibody response against Streptococcus mutans GbpB. Moreover, other caries-related etiological factors were also investigated. Design: 36-60 month-old children were grouped into Caries-Free (CF, n = 19), Early Childhood Caries (ECC, n = 17) and Severe Early Childhood Caries (S-ECC, n = 21). Data from socio-economic-cultural status, oral hygiene habits and dietary patterns were obtained from a questionnaire and a food-frequency diary filled out by parents. Saliva was collected from children for microbiological analysis and detection of salivary IgA antibody reactive with S. mutans GbpB in western blot. Results: S-ECC children had reduced family income compared to those with ECC and CF. There was difference between CF and caries groups (ECC and S-ECC) in MS counts. Positive correlations between salivary IgA antibody response against GbpB and MS counts were found when the entire population was evaluated. When children with high MS counts were compared, S-ECC group showed significantly lower IgA antibody levels to GbpB compared to CF group. This finding was not observed for the ECC group. Conclusions: This study suggests that children with S-ECC have reduced salivary IgA immune responses to S. mutans GbpB, potentially compromising their ability to modify MS infection and its cariogenic potential. Furthermore, a reduced family income and high levels of MS were also associated with S-ECC. (C) 2016 Elsevier Ltd. All rights reserved. 67
22 27 Sao Paulo Research Foundation (FAPESP), Sao Paulo, SP, Brazil [2012/19235-5, 2013/12167-7] Coordination for the Improvement of Higher Education Personnel (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)