Relationship Between The Iga Antibody Response Against Streptococcus Mutans Gbpb And Severity Of Dental Caries In Childhood

dc.creatorColombo
dc.creatorNH; Pereira
dc.creatorJA; da Silva
dc.creatorMER; Ribas
dc.creatorLFF; Parisotto
dc.creatorTM; Mattos-Graner
dc.creatorRD; Smith
dc.creatorDJ; Duque
dc.creatorC
dc.date2016
dc.date2016-12-06T18:29:22Z
dc.date2016-12-06T18:29:22Z
dc.date.accessioned2018-03-29T02:01:54Z
dc.date.available2018-03-29T02:01:54Z
dc.identifier1879-1506
dc.identifierArchives Of Oral Biology. PERGAMON-ELSEVIER SCIENCE LTD, n. 67, p. 22 - 27.
dc.identifier0003-9969
dc.identifierWOS:000375508400004
dc.identifier10.1016/j.archoralbio.2016.03.006
dc.identifierhttp://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S0003996916300632
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/319763
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1310529
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionObjective: Explore the associations between the severity of dental caries in childhood, mutans streptococci (MS) levels and IgA antibody response against Streptococcus mutans GbpB. Moreover, other caries-related etiological factors were also investigated. Design: 36-60 month-old children were grouped into Caries-Free (CF, n = 19), Early Childhood Caries (ECC, n = 17) and Severe Early Childhood Caries (S-ECC, n = 21). Data from socio-economic-cultural status, oral hygiene habits and dietary patterns were obtained from a questionnaire and a food-frequency diary filled out by parents. Saliva was collected from children for microbiological analysis and detection of salivary IgA antibody reactive with S. mutans GbpB in western blot. Results: S-ECC children had reduced family income compared to those with ECC and CF. There was difference between CF and caries groups (ECC and S-ECC) in MS counts. Positive correlations between salivary IgA antibody response against GbpB and MS counts were found when the entire population was evaluated. When children with high MS counts were compared, S-ECC group showed significantly lower IgA antibody levels to GbpB compared to CF group. This finding was not observed for the ECC group. Conclusions: This study suggests that children with S-ECC have reduced salivary IgA immune responses to S. mutans GbpB, potentially compromising their ability to modify MS infection and its cariogenic potential. Furthermore, a reduced family income and high levels of MS were also associated with S-ECC. (C) 2016 Elsevier Ltd. All rights reserved.
dc.description67
dc.description
dc.description22
dc.description27
dc.descriptionSao Paulo Research Foundation (FAPESP), Sao Paulo, SP, Brazil [2012/19235-5, 2013/12167-7]
dc.descriptionCoordination for the Improvement of Higher Education Personnel (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description
dc.description
dc.description
dc.languageEnglish
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.publisherOXFORD
dc.relationArchives Of Oral Biology
dc.rightsfechado
dc.sourceWOS
dc.subjectEarly Childhood Caries
dc.subjectImunoglobulin A
dc.subjectS. Mutans
dc.subjectGlucan Binding Proteins
dc.titleRelationship Between The Iga Antibody Response Against Streptococcus Mutans Gbpb And Severity Of Dental Caries In Childhood
dc.typeArtículos de revistas


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