Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)The first total synthesis of (-)-marinisporolide C was performed in 25 steps (longest linear sequence) and an overall yield. of 1%. Due to the high degree of convergence and robustness, the C9-C35 fragment that corresponds to polyol portion was obtained in gram quantity: Highlights, of this synthesis include five highly stereoselective aldol reactions responsible for the construction Of five C-C bond's and six stereogenic Centers: Additionally, a very efficient Julia-Kocienski reaction was used to install a C22-C23 double bond, and the macrocyclic was closed using an intramolecular Horner-Wadsworth-Emmons olefination.1724 62786281Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)[2011/06721-6]Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)