Total Synthesis Of The Oxopolyene Macrolide (-)-marinisporolide C

dc.creatorDias
dc.creatorLuiz C.; de Lucca
dc.creatorEmilio C.
dc.creatorJr.
dc.date2015-DEC
dc.date2016-06-07T13:36:05Z
dc.date2016-06-07T13:36:05Z
dc.date.accessioned2018-03-29T01:51:30Z
dc.date.available2018-03-29T01:51:30Z
dc.identifier
dc.identifierTotal Synthesis Of The Oxopolyene Macrolide (-)-marinisporolide C. Amer Chemical Soc, v. 17, p. 6278-6281 DEC-2015.
dc.identifier1523-7060
dc.identifierWOS:000366878300086
dc.identifier10.1021/acs.orglett.5b03352
dc.identifierhttp://pubs.acs.org/doi/abs/10.1021/acs.orglett.5b03352
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/244244
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1307942
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionThe first total synthesis of (-)-marinisporolide C was performed in 25 steps (longest linear sequence) and an overall yield. of 1%. Due to the high degree of convergence and robustness, the C9-C35 fragment that corresponds to polyol portion was obtained in gram quantity: Highlights, of this synthesis include five highly stereoselective aldol reactions responsible for the construction Of five C-C bond's and six stereogenic Centers: Additionally, a very efficient Julia-Kocienski reaction was used to install a C22-C23 double bond, and the macrocyclic was closed using an intramolecular Horner-Wadsworth-Emmons olefination.
dc.description17
dc.description24
dc.description
dc.description6278
dc.description6281
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description[2011/06721-6]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description
dc.description
dc.description
dc.languageen
dc.publisherAMER CHEMICAL SOC
dc.publisher
dc.publisherWASHINGTON
dc.relationORGANIC LETTERS
dc.rightsfechado
dc.sourceWOS
dc.subjectMediated Aldol Reactions
dc.subjectOxygenated Methyl Ketones
dc.subjectEnantioselective Total-synthesis
dc.subject1,5-asymmetric Induction
dc.subjectStereocontrolled Synthesis
dc.subjectStereoselective-synthesis
dc.subjectAntibiotic Roxaticin
dc.subjectBeta-hydroxyketones
dc.subjectDirected Reduction
dc.subjectAddition-reactions
dc.titleTotal Synthesis Of The Oxopolyene Macrolide (-)-marinisporolide C
dc.typeArtículos de revistas


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