Artículos de revistas
Blood Metabolome Changes Before And After Bariatric Surgery: A 1h Nmr-based Clinical Investigation
Registro en:
Omics A Journal Of Integrative Biology. Mary Ann Liebert Inc., v. 19, n. 5, p. 318 - 327, 2015.
15362310
10.1089/omi.2015.0009
2-s2.0-84929072444
Institución
Resumen
Excessive body fat and obesity have adverse health effects and result in significant morbidity such as type 2 diabetes mellitus. The health burden of obesity can be reduced with the Roux-en-Y gastric bypass (RYGB) weight-loss bariatric surgery. Little is known on the molecular changes that occur at the metabolome level before and after bariatric surgery, with a view to clinical biomarker development. Hence, we employed a metabolomics approach in 10 obese diabetic patients who underwent bariatric surgery. Metabolomics data were obtained by T<inf>2</inf>- and diffusion-edited hydrogen nuclear magnetic resonance (1H NMR) spectra to monitor the metabolic and lipoprotein profiles, and gas chromatography-mass spectrometry (CG-MS) to access the fatty acid profile before and 12 months after RYGB. Using hierarchical partial least squares discriminant analysis, we found that RYGB induces several key metabolic alterations associated with glucose homeostasis, as well as fatty acid and amino acid metabolism. The levels of lactate (Krebs' intermediate cycle) decreased after RYGB. The leucine, isoleucine, valine, lactate, and glucose levels were higher in the samples before RYGB (p<0.05). Additionally, the levels of very low-density lipoprotein, unsaturated lipids, and N-acetyl-glycoprotein were higher before RYGB. By contrast, levels of the high-density lipoprotein and phosphatidylcholine were higher after bariatric surgery. These results collectively offer important holistic integrative biology data to develop future clinically relevant metabolomics biomarkers related to bariatric surgery in connection with obesity. © 2015, Mary Ann Liebert, Inc. 19 5 318 327 Adams, T.D., Gress, R.E., Smith, S.C., Longer mortality after gastric bypass surgery (2007) N Engl J Med, 357, pp. 753-761 Ala-Korpela, M., Korhonen, A., Keisala, J., 1H NMRbased absolute quantitation of human lipoproteins and their lipid contents directly from plasma (1994) J Lipid Res, 35, pp. 2292-2304 Ala-Korpela, M., Lankinen, N., Salminen .A, The inherent accuracy of 1H NMR spectroscopy to quantify plasma lipoproteins is subclass dependent (2007) Atherosclerosis, 190, pp. 352-358 Ballabio, D., Consonni, V., Classification tools in chemistry Part 1: Linear models (2013) PLS-DA. Anal Methods, 5, pp. 3790-3798 Barron, J.T., Barany, M., Gu, L., Parrillo, J.E., Metabolic fate of glucose in vascular smooth muscle during contraction induced by noradrenaline (1998) J Mol Cell Cardiol, 30, pp. 709-719 Batch, B.C., Shah, S.H., Newgard, C.B., Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness (2013) Metabolism, 62, pp. 961-969 Bell, J.D., Brown, J.C., Nicholson, J.K., Sadler, P.J., Assignment of resonances for 'acute phase' glycoproteins in high resolution proton NMR spectra of human blood plasma (1987) FEBS Lett, 215, pp. 311-315 Buchwald, H., Estok, R., Fahrbach, K., Weight and type 2 diabetes after bariatric surgery: Systematic review and meta-analysis (2009) Am J Med, 122, pp. 248-256 Catalan, V., Gomez-Ambrosi, J., Ramirez, B., Proinflammatory cytokines in obesity: Impact of type 2 diabetes mellitus and gastric bypass (2007) Obesity Surg, 17, pp. 1464-1474 Croset, M., Brossard, N., Polette, A., Lagarde, M., Characterization of plasma unsaturated lysophosphatidylcholines in human and rat (2000) Biochem J, 345, pp. 61-67 Dandara, C., Huzair, F., Borda-Rodriguez, A., Chirikure, S., Okpechi, I., Warnich, L., Masimirembwa, C., H3Africa andthe African life sciences ecosystem: Building sustainable innovation (2014) OMICS, 18, pp. 733-739 Duarte, I.F., Goodfellow, B.J., Barros, A., Metabolic characterisation of plasma in juveniles with glycogen storage disease type 1a (GSD1a) by high-resolution 1H NMR spectroscopy (2007) NMR Biomed, 20, pp. 401-412 Dyrby, M., Petersen, M., Whittaker, A.K., Lambert, L., Nørgaard, L., Bro, R., Engelsen, S.B., Analysis of lipoproteins using 2D diffusion-edited NMR spectroscopy and multi-way chemometrics (2005) Anal Chim Acta, 531, pp. 209-216 Eriksson, L., Johansson, E., Lindgren, F., Sjöström, M., Wold, S., Megavariate analysis of hierarchical QSAR data (2002) J Computer-Aided Mol Design, 16, pp. 711-726 Friedrich, N., Budde, K., Wolf, T., Short-term changes of the urine metabolome after bariatric surgery (2012) OMICS, 16, pp. 612-620 Folch, J., Lees, M., Stanley, G.H.S., A simple method for the isolation and purification of total lipids from animal tissues (1957) J Biol Chem, 226, pp. 497-509 Geloneze, B., Tambascia, M.A., Pareja, J.C., Repetto, E.M., Magna, L.A., The insulin tolerance test in morbidly obese patients undergoing bariatric surgery (2001) Obesity Res, 9, pp. 763-769 Iverson, S.J., Lang, S.L.C., Cooper, M.H., Comparison of the Bligh and Dyer and Folch methods for total lipid determination in a broad range of marine tissue (2001) Lipids, 36, pp. 1283-1287 Jung, J.Y., Kim, I.Y., Kim, Y.N., 1H NMR-based metabolite profiling of diet-induced obesity in a mouse mode (2012) BMB Rep, 45, pp. 419-424 Khoo, C.M., Muehlbauer, M.J., Stevens, R.D., Pamuklar, Z., Chen, J., Newgard, C.B., Torquati, A., Postprandial metabolite profiles reveal differential nutrient handling after bariatric surgery compared with matched caloric restriction (2013) Ann Surg, 19, pp. 1-5 King, I.B., Lemaitre, R.N., Kestin, M., Effect of a lowfat diet on fatty acid composition in red cells, plasma phospholipids, and cholesterol esters: Investigation of a biomarker of total fat intake (2006) Am J Clin Nutr, 83, pp. 227-236 Laferrère, B., Reilly, D., Arias, S., Differential metabolic impact of gastric bypass surgery versus dietary intervention in obese diabetic individuals despite identical weight loss (2011) Sci Translat Med, 3, pp. 80-82 Layman, D.K., Baum, J.I., Dietary protein impact on glycemic control during weight loss (2004) J Nutr, 134, pp. 968S-973S Lima, M.M.O., Pareja, J.C., Alegre, S.M., Acute effect of Roux-En-Y gastric bypass on whole-body insulin sensitivity: A study with the euglycemic-hyperinsulinemic clamp (2010) J Clin Endocrinol Metab, 95, pp. 3871-3875 Lindon, J.C., Holmes, E., Nicholson, J.K., So what's the deal with metabonomics (2003) Anal Chem, 75, pp. 384-391 Lindon, J.C., Nicholson, J.K., Spectroscopic and statistical techniques for information recovery in metabonomics and metabolomics (2008) Ann Rev Anal Chem, 1, pp. 45-69 Lindqvist, A., Spe'gel, P., Ekelund, M., Mulder, H., Hedenbro, L.G.J., Wierup, N., Effects of ingestion routes on hormonal and metabolic profiles in gastric-bypassed humans (2013) J Clin Endocrinol Metab, 98, pp. 856-861 Liou, A.P., Paziuk, M., Luevano, J.M., Jr., Machineni, S., Turnbaugh, P.J., Kaplan, L.M., Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity (2013) Sci Translat Med, 5, pp. 1-11 Liu, M., Tang, H., Nicholson, J.K., Lindon, J.C., Use of 1H NMR-determined diffusion coefficients to characterize lipoprotein fractions in human blood plasma (2002) Magnet Reson Chem, 40, pp. S83-S88 Lopes, T.I.B., Rimland, C.A., Nagassaki, S., Geloneze, B., Marsaioli, A.J., A chemometric model applied to fatty acid determination in blood (2013) J Brazil Chem Soc, 24, pp. 1599-1605 Ludwig, C., Viant, M.R., Two-dimensional J-resolved NMR spectroscopy: Review of a key methodology in the metabolomics toolbox (2010) Phytochem Anal, 21, pp. 22-32 Marengo, E., Todeschini, R., A new algorithm for optimal, distance-based experimental design (1992) Chemomet Intelligent Lab Systems, 16, pp. 37-44 Morinigo, R., Lacy, A.M., Casamitjana, R., Delgado, S., Gomis, R., Vidal, J., GLP-1 and changes in glucose tolerance following gastric bypass surgery in morbidly obese Individuals (2006) Obesity Surg, 16, pp. 1594-1601 Morris, C., O'grada, C., Ryan, M., Roche, H.M., Gibney, M.J., Gibney, E.R., Brennan, L., The 1 relationship between BMI and metabolomics profiles: A focus on amino acids (2012) Proc Nutr Soc, 71, pp. 634-638 Muoio, D.M., Koves, T.R., Lipid-induced metabolic dysfunction in skeletal muscle (2007) Novartis Found Symp, 286, pp. 24-38 Mutch, D.M., Fuhrmann, J.C., Rein, D., Wiemer, J.C., Bouillot, J.L., Poitou, C., Clement, K., Metabolite profiling identifies candidate markers reflecting the clinical adaptations associated with roux-en-y gastric bypass surgery (2009) PLoS ONE, 4, pp. e7905-e7917 Newgard, C.B., An, J., Bain, J.R., Muehlbauer, M.J., Stevens, R.D., Lien, L.F., A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance (2009) Cell Metab, 9, pp. 311-326 Otvos, J.D., Jeyarajah, E.J., Bennett, D.W., Krauss, R.M., Development of a proton nuclear magnetic resonance spectroscopic method for determining plasma lipoprotein concentrations and subspecies distributions from a single, rapid measurement (1992) Clin Chem, 38, pp. 1632-1638 Patti, G.J., Yanes, O., Siuzdak, G., Innovation: Metabolomics: The apogee of the omics trilogy (2012) Nature Rev Mol Cell Biol, 13, pp. 263-269 Petersen, M., Dyrby, M., Toubro, S., Engelsen, S.B., Norgaard, L., Pedersen, H.T., Dyerberg, J., Quantification of lipoprotein subclasses by proton nuclear magnetic resonance-based partial least-squares regression models (2005) Clin Chem, 51, pp. 1457-1461 Rodriguez, A.R., Reglero, G., Ibanez, E., Recent trends in the advanced analyses of bioactive fatty acids (2010) J Pharm Biomed Anal, 51, pp. 305-326 Savorani, F., Tomasi, G., Engelsen, S.B., Icoshift: A versatile tool for the rapid alignment of 1D NMR spectra (2010) J Magnet Reson, 202, pp. 190-202 Tiziani, S., Emwas, A.H., Lodi, A., Ludwig, C., Bunce, C.M., Viant, M.R., Gunther, U.L., Optimized metabolite extraction from blood serum for 1H nuclear magnetic resonance spectroscopy (2008) Anal Biochem, 377, pp. 16-23 Williams, D.B., Hagedorn, J.C., Lawson, E.H., Gastric bypass reduces biochemical cardiac risk factors (2007) Surg Obesity Related Dis, 3, pp. 8-13 Wishart, D.S., Quantitative metabolomics using NMR (2008) Trends Anal Chem, 27, pp. 228-237