Artículos de revistas
Impaired Dipsogenic And Renal Response To Repetitive Intracerebroventricular Angiotensin Ii (angii) Injections In Rats.
Registration in:
Journal Of The Renin-angiotensin-aldosterone System : Jraas. v. 12, n. 3, p. 161-8, 2011-Sep.
1752-8976
10.1177/1470320310392617
21393358
Author
Zapparoli, Adriana
Figueiredo, José Francisco
Boer, Patricia Aline
Rocha Gontijo, José Antonio
Institutions
Abstract
The role of the central nervous system (CNS) in the control of blood pressure and hydrosaline homeostasis has been demonstrated by several studies. While circulating angiotensin II (AngII) tends to retain sodium by a direct renal action as well as through aldosterone release, stimulation of brain AngII receptors has been reported to induce natriuresis. Repetitive intracerebroventricular AngII injection was recently demonstrated to be capable of leading to desensitisation of the dipsogenic effect of AngII stimuli. The aim of the current study was to investigate a possible central desensitisation to AngII stimuli by observing the effects of a low-concentration solution of AngII on the dipsogenic and natriuretic mechanisms in conscious rats, compared with appropriate age-matched 0.15 M NaCl-injected subjects, as evaluated by lithium clearance. The present report confirmed earlier reports on the potent natriuretic and dipsogenic effects of central AngII receptor stimulation. Natriuresis is mediated by a decrease in sodium reabsorption in the proximal and post-proximal tubule segments of the nephron. The current findings lend further support to the idea that AngII, in the CNS, is instrumental in the regulation of body fluid homeostasis. The magnitude of the dipsogenic and renal response to AngII was significantly decreased by repetitive stimulus. 12 161-8