Impaired Dipsogenic And Renal Response To Repetitive Intracerebroventricular Angiotensin Ii (angii) Injections In Rats.

dc.creatorZapparoli, Adriana
dc.creatorFigueiredo, José Francisco
dc.creatorBoer, Patricia Aline
dc.creatorRocha Gontijo, José Antonio
dc.date2011-Sep
dc.date2015-11-27T13:21:09Z
dc.date2015-11-27T13:21:09Z
dc.date.accessioned2018-03-29T01:12:41Z
dc.date.available2018-03-29T01:12:41Z
dc.identifierJournal Of The Renin-angiotensin-aldosterone System : Jraas. v. 12, n. 3, p. 161-8, 2011-Sep.
dc.identifier1752-8976
dc.identifier10.1177/1470320310392617
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/21393358
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/199319
dc.identifier21393358
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1299552
dc.descriptionThe role of the central nervous system (CNS) in the control of blood pressure and hydrosaline homeostasis has been demonstrated by several studies. While circulating angiotensin II (AngII) tends to retain sodium by a direct renal action as well as through aldosterone release, stimulation of brain AngII receptors has been reported to induce natriuresis. Repetitive intracerebroventricular AngII injection was recently demonstrated to be capable of leading to desensitisation of the dipsogenic effect of AngII stimuli. The aim of the current study was to investigate a possible central desensitisation to AngII stimuli by observing the effects of a low-concentration solution of AngII on the dipsogenic and natriuretic mechanisms in conscious rats, compared with appropriate age-matched 0.15 M NaCl-injected subjects, as evaluated by lithium clearance. The present report confirmed earlier reports on the potent natriuretic and dipsogenic effects of central AngII receptor stimulation. Natriuresis is mediated by a decrease in sodium reabsorption in the proximal and post-proximal tubule segments of the nephron. The current findings lend further support to the idea that AngII, in the CNS, is instrumental in the regulation of body fluid homeostasis. The magnitude of the dipsogenic and renal response to AngII was significantly decreased by repetitive stimulus.
dc.description12
dc.description161-8
dc.languageeng
dc.relationJournal Of The Renin-angiotensin-aldosterone System : Jraas
dc.relationJ Renin Angiotensin Aldosterone Syst
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAngiotensin Ii
dc.subjectAnimals
dc.subjectBody Weight
dc.subjectDose-response Relationship, Drug
dc.subjectDrinking Behavior
dc.subjectInjections, Intraventricular
dc.subjectKidney
dc.subjectKidney Function Tests
dc.subjectLithium
dc.subjectMicroinjections
dc.subjectPotassium
dc.subjectRats
dc.subjectSodium
dc.subjectThirst
dc.titleImpaired Dipsogenic And Renal Response To Repetitive Intracerebroventricular Angiotensin Ii (angii) Injections In Rats.
dc.typeArtículos de revistas


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