dc.creatorLorencini, Márcio
dc.creatorSilva, Juliete A F
dc.creatorde la Hoz, Cristiane L R
dc.creatorCarvalho, Hernandes F
dc.creatorStach-Machado, Dagmar R
dc.date2009-Feb
dc.date2015-11-27T13:15:53Z
dc.date2015-11-27T13:15:53Z
dc.date.accessioned2018-03-29T01:10:02Z
dc.date.available2018-03-29T01:10:02Z
dc.identifierHistology And Histopathology. v. 24, n. 2, p. 157-66, 2009-Feb.
dc.identifier1699-5848
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/19085832
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/198630
dc.identifier19085832
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1298863
dc.descriptionIn periodontal disease, extensive disorganization of the extracellular matrix promotes the loss of adhesion between the teeth and periodontium. A previous study suggested a reduction in the area occupied by collagen in the gingiva, during the first week of periodontal disease induction, however, the remaining fibers were more compact and thicker. Therefore, it was decided to investigate which of the MMP-2, -9, -14 and RECK, an MMP inhibitor, were involved in these modifications taking place in early gingivitis induced by ligature. The results of gene expression analysis indicated no changes for RECK. MMP-14 showed a reduction at 7 days of inflammation, and there was an immediate increase in MMP-2 gene expression and enzymatic activity, apparently by the stimulation of resident cells such as fibroblasts. A peak of MMP-9 expression 5 days after ligature followed after the peak of enzymatic activity found two days earlier. This pattern was consistent with the kinetics of macrophage and neutrophil recruitment. Immunohistochemistry suggested that MMP-9 was produced by both resident and inflammatory cells. Based on this evidence, it is suggested that extracellular matrix remodeling is related to MMP-2 and -9 production and activation. This allowed us to conclude that the host inflammatory response represents a significant factor for the advance of periodontal diseases.
dc.description24
dc.description157-66
dc.languageeng
dc.relationHistology And Histopathology
dc.relationHistol. Histopathol.
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectCollagen
dc.subjectEnzyme Inhibitors
dc.subjectExtracellular Matrix
dc.subjectFibroblasts
dc.subjectGingiva
dc.subjectGingivitis
dc.subjectInflammation
dc.subjectMacrophages
dc.subjectMale
dc.subjectMatrix Metalloproteinase 14
dc.subjectMatrix Metalloproteinase 2
dc.subjectMatrix Metalloproteinase 9
dc.subjectMatrix Metalloproteinases
dc.subjectNeutrophils
dc.subjectRats
dc.subjectRats, Wistar
dc.titleChanges In Mmps And Inflammatory Cells In Experimental Gingivitis.
dc.typeArtículos de revistas


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