Evidence For The Involvement Of Endogenous Atp And P2x Receptors In Tmj Pain.

dc.creatorOliveira, Maria Cláudia G
dc.creatorParada, Carlos Amílcar
dc.creatorVeiga, Maria Cecília Ferraz Arruda
dc.creatorRodrigues, Luciane Rocha
dc.creatorBarros, Silvana Pereira
dc.creatorTambeli, Cláudia Herrera
dc.date2005-Feb
dc.date2015-11-27T13:02:01Z
dc.date2015-11-27T13:02:01Z
dc.date.accessioned2018-03-29T01:00:42Z
dc.date.available2018-03-29T01:00:42Z
dc.identifierEuropean Journal Of Pain (london, England). v. 9, n. 1, p. 87-93, 2005-Feb.
dc.identifier1090-3801
dc.identifier10.1016/j.ejpain.2004.04.006
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/15629879
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/196227
dc.identifier15629879
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1296460
dc.descriptionEvidence is accumulating which supports a role for ATP in the initiation of pain by acting on P2X receptors expressed on nociceptive afferent nerve terminals. To investigate whether these receptors play a role in temporomandibular (TMJ) pain, we studied the presence of functional P2X receptors in rat TMJ by examining the nociceptive behavioral response to the application of the selective P2X receptor agonist alpha,beta-methylene ATP (alpha,beta-meATP) into the TMJ region of rat. The involvement of endogenous ATP in the development of TMJ inflammatory hyperalgesia was also determined by evaluating the effect of the general P2 receptor antagonist pyridoxal-phosphate-6-azophenyl-2',4'-disulphonic acid (PPADS) on carrageenan-induced TMJ inflammatory hyperalgesia. Application of alpha,beta-meATP into the TMJ region of rats produced significant nociceptive responses that were significantly reduced by the co-application of lidocaine N-ethyl bromide quaternary salt, QX-314, (2%) or of the P2 receptor antagonist PPADS. Co-application of PPADS with carrageenan into the TMJ significantly reduced inflammatory hyperalgesia. The results indicate that functional P2X receptors are present in the TMJ and suggest that endogenous ATP may play a role in TMJ inflammatory pain mechanisms possibly by acting primarily in these receptors.
dc.description9
dc.description87-93
dc.languageeng
dc.relationEuropean Journal Of Pain (london, England)
dc.relationEur J Pain
dc.rightsfechado
dc.rights
dc.sourcePubMed
dc.subjectAdenosine Triphosphate
dc.subjectAnimals
dc.subjectAnti-inflammatory Agents
dc.subjectArthralgia
dc.subjectArthritis
dc.subjectCarrageenan
dc.subjectDisease Models, Animal
dc.subjectDown-regulation
dc.subjectLidocaine
dc.subjectMale
dc.subjectNociceptors
dc.subjectPurinergic P2 Receptor Agonists
dc.subjectPurinergic P2 Receptor Antagonists
dc.subjectPyridoxal Phosphate
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectReceptors, Purinergic P2
dc.subjectReceptors, Purinergic P2x
dc.subjectSensory Receptor Cells
dc.subjectTemporomandibular Joint
dc.subjectTemporomandibular Joint Disorders
dc.titleEvidence For The Involvement Of Endogenous Atp And P2x Receptors In Tmj Pain.
dc.typeArtículos de revistas


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