Artículos de revistas
Interference of dexamethasone in the pulmonary cycle of Strongyloides venezuelensis in rats
Registro en:
American Journal Of Tropical Medicine And Hygiene. Amer Soc Trop Med & Hygiene, v. 79, n. 4, n. 571, n. 578, 2008.
0002-9637
WOS:000259858000017
Autor
Tefe-Silva, C
Souza, DI
Ueta, MT
Floriano, EM
Faccioli, LH
Ramos, SG
Institución
Resumen
The aim of this study was to investigate the interference of a daily treatment of dexamethasone in the pulmonary cycle of Strongyloides venezuelensis infection in rats. Three principal effects were found: 1) increased alveolar hemorrhagic inflammation provoked by the passage of larvae into alveolar spaces; 2) significant decrease of eosinophil and mast cell migration to the axial septum of the lungs; and 3) impaired formation of the reticular fiber network, interfering with granuloma organization. This study showed that the use of drugs with immunomodulatory actions, such as dexamethasone, in addition to interfering with the morbidity from the pulmonary cycle of S. venezuelensis infection, may contribute to showing the mechanisms involved in its pathogenesis. o TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE AGOSTO DE 2015. 79 4 571 578