Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)A few hydrocarbons in gasoline display relatively high solubility in water and may function therefore as its characteristic set of natural markers. These markers are detected from an aqueous gasoline extract via membrane introduction mass spectrometry (MIMS) producing characteristic chemical profiles. MIMS adds a second selectivity criterion detecting only the water soluble hydrocarbons that most easily permeate through a silicone membrane. MIMS screening and the use of artificial markers for gasoline with similar chemical properties (high water solubility and membrane permeability) as those of its natural markers is proposed. MIMS provides a reliable screening method for natural and artificial markers in gasoline for its typification and to monitor adulteration and origin.33751754Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Financing Agency for Studies and Projects (FINEP)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)