Artículos de revistas
Towards the total synthesis of stawamycin. Synthesis of C11-C21 fragment.
Registro en:
Journal Of The Brazilian Chemical Society. Soc Brasileira Quimica, v. 12, n. 4, n. 463, n. 466, 2001.
0103-5053
WOS:000169920500003
10.1590/S0103-50532001000400003
Autor
Dias, LC
Jardim, LSA
Ferreira, AA
Soarez, HU
Institución
Resumen
The carbocyclic (C11-C21) fragment of Stawamycin has been prepared by a sequence involving 11 steps (10% overall yield) from methyl (R)-(-)-3-hydroxy-2-methylpropionate. Key steps are Pd-catalyzed Stille coupling reaction between a vinyl iodide and a vinylstannane followed by an intramolecular Diels-Alder cycloaddition reaction to afford the desired adduct as the major isomer together with three other possible adducts in 78% overall yield. 12 4 463 466