Towards the total synthesis of stawamycin. Synthesis of C11-C21 fragment.

dc.creatorDias, LC
dc.creatorJardim, LSA
dc.creatorFerreira, AA
dc.creatorSoarez, HU
dc.date2001
dc.dateJUL-AUG
dc.date2014-11-15T17:40:30Z
dc.date2015-11-26T17:20:58Z
dc.date2014-11-15T17:40:30Z
dc.date2015-11-26T17:20:58Z
dc.date.accessioned2018-03-29T00:08:31Z
dc.date.available2018-03-29T00:08:31Z
dc.identifierJournal Of The Brazilian Chemical Society. Soc Brasileira Quimica, v. 12, n. 4, n. 463, n. 466, 2001.
dc.identifier0103-5053
dc.identifierWOS:000169920500003
dc.identifier10.1590/S0103-50532001000400003
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77790
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/77790
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77790
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1283258
dc.descriptionThe carbocyclic (C11-C21) fragment of Stawamycin has been prepared by a sequence involving 11 steps (10% overall yield) from methyl (R)-(-)-3-hydroxy-2-methylpropionate. Key steps are Pd-catalyzed Stille coupling reaction between a vinyl iodide and a vinylstannane followed by an intramolecular Diels-Alder cycloaddition reaction to afford the desired adduct as the major isomer together with three other possible adducts in 78% overall yield.
dc.description12
dc.description4
dc.description463
dc.description466
dc.languageen
dc.publisherSoc Brasileira Quimica
dc.publisherSao Paulo
dc.publisherBrasil
dc.relationJournal Of The Brazilian Chemical Society
dc.relationJ. Braz. Chem. Soc.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectintramolecular Diels-Alder reaction
dc.subjectStille coupling
dc.subjectherpes virus inhibitor
dc.subjectIonophore Antibiotic X-14547a
dc.subjectCross-coupling Reactions
dc.subjectDna-binding Specificity
dc.subjectDiels-alder Reaction
dc.subjectConstruction
dc.subjectDimerization
dc.subjectIndanomycin
dc.subjectPalladium
dc.subjectReagents
dc.subjectBenzyl
dc.titleTowards the total synthesis of stawamycin. Synthesis of C11-C21 fragment.
dc.typeArtículos de revistas


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