Artículos de revistas
(R)-goniothalamin: total syntheses and cytotoxic activity against cancer cell lines
Registro en:
Bioorganic & Medicinal Chemistry. Pergamon-elsevier Science Ltd, v. 13, n. 8, n. 2927, n. 2933, 2005.
0968-0896
WOS:000228254000021
10.1016/j.bmc.2005.02.007
Autor
de Fatima, A
Kohn, LK
Antonio, MA
de Carvalho, JE
Pilli, RA
Institución
Resumen
The total syntheses of (R)-goniothalamin (1), a styryl lactone isolated from several Goniothalamus species, via catalytic asymmetric allylation of alpha-benzyloxyacetaldehyde (2), followed by ring-closing metathesis and Wittig olefination and via catalytic asymmetric allylation of trans-cinnamaldehyde (12), followed by ring-closing metathesis are reported. The anti proliferative activities of (R)-1 and its Z-isomer 10 as well as of the synthetic dihydropyranone intermediates 7 and 8 against eight different cancer cell lines are also described. (c) 2005 Elsevier Ltd. All rights reserved. 13 8 2927 2933