(R)-goniothalamin: total syntheses and cytotoxic activity against cancer cell lines

dc.creatorde Fatima, A
dc.creatorKohn, LK
dc.creatorAntonio, MA
dc.creatorde Carvalho, JE
dc.creatorPilli, RA
dc.date2005
dc.dateAPR 15
dc.date2014-11-14T14:08:53Z
dc.date2015-11-26T17:15:09Z
dc.date2014-11-14T14:08:53Z
dc.date2015-11-26T17:15:09Z
dc.date.accessioned2018-03-29T00:03:24Z
dc.date.available2018-03-29T00:03:24Z
dc.identifierBioorganic & Medicinal Chemistry. Pergamon-elsevier Science Ltd, v. 13, n. 8, n. 2927, n. 2933, 2005.
dc.identifier0968-0896
dc.identifierWOS:000228254000021
dc.identifier10.1016/j.bmc.2005.02.007
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/52443
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/52443
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/52443
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1281974
dc.descriptionThe total syntheses of (R)-goniothalamin (1), a styryl lactone isolated from several Goniothalamus species, via catalytic asymmetric allylation of alpha-benzyloxyacetaldehyde (2), followed by ring-closing metathesis and Wittig olefination and via catalytic asymmetric allylation of trans-cinnamaldehyde (12), followed by ring-closing metathesis are reported. The anti proliferative activities of (R)-1 and its Z-isomer 10 as well as of the synthetic dihydropyranone intermediates 7 and 8 against eight different cancer cell lines are also described. (c) 2005 Elsevier Ltd. All rights reserved.
dc.description13
dc.description8
dc.description2927
dc.description2933
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationBioorganic & Medicinal Chemistry
dc.relationBioorg. Med. Chem.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subject(R)-goniothalamin
dc.subjectasymmetric synthesis
dc.subjectcytotoxic activity
dc.subjectcancer cells
dc.subjectCatalytic Asymmetric Allylation
dc.subjectMevinic Acid Analogs
dc.subjectChiral Lewis-acid
dc.subjectEnantioselective Syntheses
dc.subjectBis(((s)-binaphthoxy)(isopropoxy)titanium) Oxide
dc.subjectAlternative Approach
dc.subjectOrganic-synthesis
dc.subjectFormal Synthesis
dc.subjectBenzyl Ethers
dc.subjectGoniothalamin
dc.title(R)-goniothalamin: total syntheses and cytotoxic activity against cancer cell lines
dc.typeArtículos de revistas


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