Anatomical MRI study of basal ganglia in major depressive disorder

dc.creatorLacerda, ALT
dc.creatorNicoletti, MA
dc.creatorBrambilla, P
dc.creatorSassi, RB
dc.creatorMallinger, AG
dc.creatorFrank, E
dc.creatorKupfer, DJ
dc.creatorKeshavan, MS
dc.creatorSoares, JC
dc.date2003
dc.date11263
dc.date2014-11-13T16:54:23Z
dc.date2015-11-26T17:10:33Z
dc.date2014-11-13T16:54:23Z
dc.date2015-11-26T17:10:33Z
dc.date.accessioned2018-03-28T23:59:07Z
dc.date.available2018-03-28T23:59:07Z
dc.identifierPsychiatry Research-neuroimaging. Elsevier Sci Ireland Ltd, v. 124, n. 3, n. 129, n. 140, 2003.
dc.identifier0925-4927
dc.identifierWOS:000186711900001
dc.identifier10.1016/S0925-4927(03)00123-9
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77400
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/77400
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77400
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1280889
dc.descriptionThe basal ganglia form a part of the brain neuroanatomic circuits that may be involved in mood regulation. Decreases in basal ganglia volumes have been previously reported in major depressive disorder patients in comparison to healthy controls. In this study, we measured caudate, putamen, and globus pallidus volumes in 25 patients with major depressive disorder (4 M; age +/- S.D. = 41 +/- 11 years) and 48 healthy controls (29 M; age +/- S.D. = 35 +/- 10 years), using high-resolution magnetic resonance imaging (MRI), in an attempt to replicate prior findings. Unlike most previous studies, we did not find significant differences between patient and control groups in basal ganglia volumetric measures. Nonetheless, there was a significant interaction between diagnosis and cerebral hemisphere, with MDD patients showing decreased asymmetry in globus pallidus volumes in comparison with healthy controls. Furthermore, in the patient group, left putamen volumes correlated inversely with length of illness, and left globus pallidus volume correlated directly with number of prior depressive episodes. These findings suggest that abnormalities in lateralization and possibly neurodegenerative changes in basal ganglia structures participate in the pathophysiology of major depressive disorder. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.
dc.description124
dc.description3
dc.description129
dc.description140
dc.languageen
dc.publisherElsevier Sci Ireland Ltd
dc.publisherClare
dc.publisherIrlanda
dc.relationPsychiatry Research-neuroimaging
dc.relationPsychiatry Res. Neuroimaging
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectneuroimaging
dc.subjectcaudate
dc.subjectputamen
dc.subjectglobus pallidus
dc.subjectmood disorders
dc.subjectunipolar depression
dc.subjectmagnetic resonance imaging
dc.subjectMagnetic-resonance Spectroscopy
dc.subjectPhoton-emission Tomography
dc.subjectMood Disorders
dc.subjectUnipolar Depression
dc.subjectNeuropsychiatric Disorders
dc.subjectParkinsons-disease
dc.subjectBipolar Disorder
dc.subjectMetabolic Rates
dc.subjectVolume
dc.subjectBrain
dc.titleAnatomical MRI study of basal ganglia in major depressive disorder
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución