Obsessive-compulsive disorder: Influence of age at onset on comorbidity patterns
European Psychiatry, v. 23, n. 3, p. 187-194, 2008.
de Mathis, Maria Alice
do Rosario, Maria Conceição
Diniz, Juliana Belo
Torres, Albina Rodrigues
Shavitt, Roseli Gedanki
Ferrão, Ygor Arzeno
de Bragança Pereira, Carlos Alberto
Miguel, Eurípedes Constantino
Purpose: This study investigates the influence of age at onset of OCS on psychiatric comorbidities, and tries to establish a cut-off point for age at onset. Methods: Three hundred and thirty OCD patients were consecutively recruited and interviewed using the following structured interviews: Yale-Brown Obsessive Compulsive Scale; Yale Global Tic Severity Scale and the Structured Clinical Interview for DSM-IV. Data were analyzed with regression and cluster analysis. Results: Lower age at onset was associated with a higher probability of having comorbidity with tic, anxiety, somatoform, eating and impulse-control disorders. Longer illness duration was associated with lower chance of having tics. Female gender was associated with anxiety, eating and impulse-control disorders. Tic disorders were associated with anxiety disorders and attention-deficit/hyperactivity disorder. No cut-off age at onset was found to clearly divide the sample in homogeneous subgroups. However, cluster analyses revealed that differences started to emerge at the age of 10 and were more pronounced at the age of 17, suggesting that these were the best cut-off points on this sample. Conclusions: Age at onset is associated with specific comorbidity patterns in OCD patients. More prominent differences are obtained when analyzing age at onset as an absolute value. © 2008 Elsevier Masson SAS. All rights reserved.
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Universidade de São Paulo (USP); Universidade Estadual Paulista (UNESP); Porto Alegre Institute University Center; Obsessive-Compulsive Disorder Brazilian Consortium (C-TOC) (2008-04-01)Purpose: This study investigates the influence of age at onset of OCS on psychiatric comorbidities, and tries to establish a cut-off point for age at onset. Methods: Three hundred and thirty OCD patients were consecutively ...
De Mathis, Maria Alice; Diniz, Juliana B.; Shavitt, Roseli G.; Torres, Albina Rodrigues; Ferrão, Ygor A.; Fossaluza, Victor; Pereira, Carlos; Miguel, Eurípedes C.; Do Rosario, Maria Conceição
Universidade de São Paulo (USP); São Paulo Medical School; Universidade Estadual Paulista (UNESP); Porto Alegre Institute (2009-11-27)Introduction: Research suggests that obsessive-compulsive disorder (OCD) is not a unitary entity, but rather a highly heterogeneous condition, with complex and variable clinical manifestations. Objective: The aims of this ...