Artículos de revistas
Amoxicillin and ampicillin are not transferred to gastric juice irrespective of Helicobacter pylori status or acid blockade by omeprazole
Registro en:
Alimentary Pharmacology & Therapeutics. Blackwell Publishing Ltd, v. 16, n. 6, n. 1163, n. 1170, 2002.
0269-2813
WOS:000175838300017
10.1046/j.1365-2036.2002.01262.x
Autor
Ortiz, RAM
Calafatti, SA
Corazzi, A
Souza, JM
Deguer, M
De Souza, CAF
Marchioretto, MAM
Bernasconi, G
Ferraz, JGP
Pedrazzoli, J
Institución
Resumen
Background: The effects of proton pump inhibitors and Helicobacter pylori infection on the distribution of drugs used for the eradication of the bacteria are poorly understood. Aim: The aim of this study was to investigate the effects of a 7-day administration of 20 mg of omeprazole on the pharmacokinetics of amoxicillin and ampicillin in the plasma, saliva and gastric juice of individuals with and without H. pylori infection. Methods: Fifty-four healthy volunteers without endoscopic lesions were enrolled. Twenty-six volunteers were included in the amoxicillin study and 28 individuals in the ampicillin study. Each study had an open randomized two-period crossover design and a 21-day washout period between phases. Plasma, saliva and gastric juice concentrations of amoxicillin and ampicillin in subjects with and without omeprazole pre-treatment were measured by reversed-phase HPLC using UV detection. Results: Neither pre-treatment with omeprazole nor H. pylori infection interfered with the plasma bioavailability of amoxicillin or ampicillin, as assessed by the AUC(0-2 h) . Neither ampicillin nor amoxicillin were detected in saliva or gastric juice in any study phase. Conclusion: Short-term treatment with omeprazole does not interfere with the pharmacokinetics of amoxicillin or ampicillin. Our results also exclude the presence of a transfer mechanism for amoxicillin or ampicillin from the plasma to the gastric lumen. 16 6 1163 1170