Amoxicillin and ampicillin are not transferred to gastric juice irrespective of Helicobacter pylori status or acid blockade by omeprazole

dc.creatorOrtiz, RAM
dc.creatorCalafatti, SA
dc.creatorCorazzi, A
dc.creatorSouza, JM
dc.creatorDeguer, M
dc.creatorDe Souza, CAF
dc.creatorMarchioretto, MAM
dc.creatorBernasconi, G
dc.creatorFerraz, JGP
dc.creatorPedrazzoli, J
dc.date2002
dc.dateJUN
dc.date2014-11-19T14:37:16Z
dc.date2015-11-26T17:06:44Z
dc.date2014-11-19T14:37:16Z
dc.date2015-11-26T17:06:44Z
dc.date.accessioned2018-03-28T23:55:12Z
dc.date.available2018-03-28T23:55:12Z
dc.identifierAlimentary Pharmacology & Therapeutics. Blackwell Publishing Ltd, v. 16, n. 6, n. 1163, n. 1170, 2002.
dc.identifier0269-2813
dc.identifierWOS:000175838300017
dc.identifier10.1046/j.1365-2036.2002.01262.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/54246
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/54246
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/54246
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1279935
dc.descriptionBackground: The effects of proton pump inhibitors and Helicobacter pylori infection on the distribution of drugs used for the eradication of the bacteria are poorly understood. Aim: The aim of this study was to investigate the effects of a 7-day administration of 20 mg of omeprazole on the pharmacokinetics of amoxicillin and ampicillin in the plasma, saliva and gastric juice of individuals with and without H. pylori infection. Methods: Fifty-four healthy volunteers without endoscopic lesions were enrolled. Twenty-six volunteers were included in the amoxicillin study and 28 individuals in the ampicillin study. Each study had an open randomized two-period crossover design and a 21-day washout period between phases. Plasma, saliva and gastric juice concentrations of amoxicillin and ampicillin in subjects with and without omeprazole pre-treatment were measured by reversed-phase HPLC using UV detection. Results: Neither pre-treatment with omeprazole nor H. pylori infection interfered with the plasma bioavailability of amoxicillin or ampicillin, as assessed by the AUC(0-2 h) . Neither ampicillin nor amoxicillin were detected in saliva or gastric juice in any study phase. Conclusion: Short-term treatment with omeprazole does not interfere with the pharmacokinetics of amoxicillin or ampicillin. Our results also exclude the presence of a transfer mechanism for amoxicillin or ampicillin from the plasma to the gastric lumen.
dc.description16
dc.description6
dc.description1163
dc.description1170
dc.languageen
dc.publisherBlackwell Publishing Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationAlimentary Pharmacology & Therapeutics
dc.relationAliment. Pharmacol. Ther.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectUlcer Disease
dc.subjectInfection
dc.subjectSecretion
dc.subjectClarithromycin
dc.subjectMetronidazole
dc.subjectAntibiotics
dc.subjectSusceptibility
dc.subjectFurazolidone
dc.subjectEradication
dc.subjectResistance
dc.titleAmoxicillin and ampicillin are not transferred to gastric juice irrespective of Helicobacter pylori status or acid blockade by omeprazole
dc.typeArtículos de revistas


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