Artículos de revistas
Effects of Low Molecular Weight Sulfated Galactan Fragments From Botryocladia Occidentalis on the Pharmacological and Enzymatic Activity of Spla2 From Crotalus Durissus Cascavella
Registro en:
Protein Journal. Springer, v. 29, n. 8, n. 567, n. 571, 2010.
1572-3887
WOS:000284644400005
10.1007/s10930-010-9294-9
Autor
Toyama, MH
Toyama, DO
Torres, VM
Pontes, GC
Farias, WRL
Melo, FR
Oliveira, SCB
Fagundes, FHR
Diz, EBS
Cavada, BS
Institución
Resumen
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Low molecular weight fragments of sulfated galactans (Boc-5 and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus cascavella sPLA2 enzymatic activity. Equimolar ratios of sPLA2 to Boc-5 or Boc-10 resulted in allosteric inhibition of sPLA2. Under the conditions tested, we observed that both Boc-5 and Boc-10 strongly decreased edema, myonecrosis, and neurotoxicity induced by native sPLA2. 29 8 567 571 FAPEPS [54714-3] Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) FAPEPS [54714-3] CNPq [558193/2009-9]