Effects of Low Molecular Weight Sulfated Galactan Fragments From Botryocladia Occidentalis on the Pharmacological and Enzymatic Activity of Spla2 From Crotalus Durissus Cascavella

dc.creatorToyama, MH
dc.creatorToyama, DO
dc.creatorTorres, VM
dc.creatorPontes, GC
dc.creatorFarias, WRL
dc.creatorMelo, FR
dc.creatorOliveira, SCB
dc.creatorFagundes, FHR
dc.creatorDiz, EBS
dc.creatorCavada, BS
dc.date2010
dc.dateNOV
dc.date2014-11-17T22:22:14Z
dc.date2015-11-26T16:47:07Z
dc.date2014-11-17T22:22:14Z
dc.date2015-11-26T16:47:07Z
dc.date.accessioned2018-03-28T23:33:10Z
dc.date.available2018-03-28T23:33:10Z
dc.identifierProtein Journal. Springer, v. 29, n. 8, n. 567, n. 571, 2010.
dc.identifier1572-3887
dc.identifierWOS:000284644400005
dc.identifier10.1007/s10930-010-9294-9
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/65000
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/65000
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/65000
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1274753
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionLow molecular weight fragments of sulfated galactans (Boc-5 and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus cascavella sPLA2 enzymatic activity. Equimolar ratios of sPLA2 to Boc-5 or Boc-10 resulted in allosteric inhibition of sPLA2. Under the conditions tested, we observed that both Boc-5 and Boc-10 strongly decreased edema, myonecrosis, and neurotoxicity induced by native sPLA2.
dc.description29
dc.description8
dc.description567
dc.description571
dc.descriptionFAPEPS [54714-3]
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPEPS [54714-3]
dc.descriptionCNPq [558193/2009-9]
dc.languageen
dc.publisherSpringer
dc.publisherNew York
dc.publisherEUA
dc.relationProtein Journal
dc.relationProtein J.
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectBotryocladia occidentalis
dc.subjectCrotalus durissus cascavella
dc.subjectSecretory phospholipase A2 (sPLA2)
dc.subjectEdema
dc.subjectMyonecrosis
dc.subjectPhospholipase A(2) Homolog
dc.subjectSnake-venom
dc.subjectStructural-characterization
dc.subjectPlatelet-aggregation
dc.subjectCollilineatus Venom
dc.subjectMast-cells
dc.subjectPla(2)
dc.subjectEdema
dc.subjectHeparin
dc.subjectAlgae
dc.titleEffects of Low Molecular Weight Sulfated Galactan Fragments From Botryocladia Occidentalis on the Pharmacological and Enzymatic Activity of Spla2 From Crotalus Durissus Cascavella
dc.typeArtículos de revistas


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