Artículos de revistas
Decreased GATA3 mRNA expression in human T-cell lymphotropic virus type 1 (HTLV-1) infection
Registro en:
Scandinavian Journal Of Infectious Diseases. Taylor & Francis As, v. 32, n. 2, n. 161, n. 163, 2000.
0036-5548
WOS:000086956600008
Autor
Gilli, SCO
Salles, TSI
Saad, STO
Institución
Resumen
GATA3 is a specific T-cell transcription factor involved in the expression of T-cell receptor (TCR). In order to characterize the relationship between HTLV-I infection, which has been reported to he associated with down-regulation of genes belonging to the TCR/CD3 complex, and the transcription factor GATA3, we evaluated, by semi-quantitative RT-PCR, the expression of GATA3 gene in HTLV-1 carriers and individuals with related diseases. The study included 4 asymptomatic carriers, 2 patients with adult T-cell leukaemia/lymphoma (ATLL), 1 patient with HTLV-1 associated myelopathy (HAM)/tropical spastic paraparesis (TSP) and 7 healthy blood donors. A considerable decrease in the expression of the GATA3 mRNA was observed in all subjects infected by HTLV-1 and no expression of GATA3 mRNA was observed in 1 subject with ATLL and in 1 with HAM/TSP. 32 2 161 163