Artículos de revistas
Maspin expression in carcinoma ex pleomorphic adenoma
Registro en:
Journal Of Clinical Pathology. B M J Publishing Group, v. 58, n. 12, n. 1311, n. 1314, 2005.
0021-9746
WOS:000233462100014
10.1136/jcp.2004.025205
Autor
Martins, MT
Altemani, A
Freitas, L
Araujo, VC
Institución
Resumen
Aims: To investigate the presence and distribution of the protein maspin in carcinoma ex pleomorphic adenoma (CXPA). Methods: Maspin expression was studied by means of immunohistochemistry in 16 cases of CXPA, using the labelled polymer method. Results: According to the extent of invasion, the tumours were subdivided into: intracapsular (five cases), minimally invasive (four cases), and invasive (seven cases). Twelve patients had carcinoma with only epithelial differentiation, whereas four had a malignant myoepithelial component. Non- luminal cells in the duct- like structures of the remnant pleomorphic adenoma were strongly positive for maspin, whereas only a few luminal cells were immunopositive. A few positive cells were seen in the frequent hypocellular and hyalinised areas. Maspin was abundantly expressed, mainly in non- luminal cells, in transitional areas of CXPA with only epithelial differentiation. In frankly carcinomatous areas there was a gradual decrease in maspin expression. Almost all cells were maspin positive in CXPA with a myoepithelial component. When present, luminal cells were in general negative for maspin. Conclusions: When only epithelial cells undergo malignant transformation, maspin expression is gradually lost. In cases with a myoepithelial component, maspin expression is high, and this might be related to the tumour suppressor activity attributed to this cell. 58 12 1311 1314