| dc.creator | Martins, MT | |
| dc.creator | Altemani, A | |
| dc.creator | Freitas, L | |
| dc.creator | Araujo, VC | |
| dc.date | 2005 | |
| dc.date | DEC | |
| dc.date | 2014-11-19T19:43:46Z | |
| dc.date | 2015-11-26T16:29:05Z | |
| dc.date | 2014-11-19T19:43:46Z | |
| dc.date | 2015-11-26T16:29:05Z | |
| dc.date.accessioned | 2018-03-28T23:10:09Z | |
| dc.date.available | 2018-03-28T23:10:09Z | |
| dc.identifier | Journal Of Clinical Pathology. B M J Publishing Group, v. 58, n. 12, n. 1311, n. 1314, 2005. | |
| dc.identifier | 0021-9746 | |
| dc.identifier | WOS:000233462100014 | |
| dc.identifier | 10.1136/jcp.2004.025205 | |
| dc.identifier | http://www.repositorio.unicamp.br/jspui/handle/REPOSIP/53260 | |
| dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/53260 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/53260 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1269643 | |
| dc.description | Aims: To investigate the presence and distribution of the protein maspin in carcinoma ex pleomorphic adenoma (CXPA). Methods: Maspin expression was studied by means of immunohistochemistry in 16 cases of CXPA, using the labelled polymer method. Results: According to the extent of invasion, the tumours were subdivided into: intracapsular (five cases), minimally invasive (four cases), and invasive (seven cases). Twelve patients had carcinoma with only epithelial differentiation, whereas four had a malignant myoepithelial component. Non- luminal cells in the duct- like structures of the remnant pleomorphic adenoma were strongly positive for maspin, whereas only a few luminal cells were immunopositive. A few positive cells were seen in the frequent hypocellular and hyalinised areas. Maspin was abundantly expressed, mainly in non- luminal cells, in transitional areas of CXPA with only epithelial differentiation. In frankly carcinomatous areas there was a gradual decrease in maspin expression. Almost all cells were maspin positive in CXPA with a myoepithelial component. When present, luminal cells were in general negative for maspin. Conclusions: When only epithelial cells undergo malignant transformation, maspin expression is gradually lost. In cases with a myoepithelial component, maspin expression is high, and this might be related to the tumour suppressor activity attributed to this cell. | |
| dc.description | 58 | |
| dc.description | 12 | |
| dc.description | 1311 | |
| dc.description | 1314 | |
| dc.language | en | |
| dc.publisher | B M J Publishing Group | |
| dc.publisher | London | |
| dc.publisher | Inglaterra | |
| dc.relation | Journal Of Clinical Pathology | |
| dc.relation | J. Clin. Pathol. | |
| dc.rights | fechado | |
| dc.source | Web of Science | |
| dc.subject | Malignant Mixed Tumors | |
| dc.subject | Salivary-glands | |
| dc.subject | Breast-cancer | |
| dc.subject | Soft Palate | |
| dc.subject | Cells | |
| dc.subject | Association | |
| dc.subject | Suppressor | |
| dc.subject | Membrane | |
| dc.subject | Mammary | |
| dc.subject | Serpin | |
| dc.title | Maspin expression in carcinoma ex pleomorphic adenoma | |
| dc.type | Artículos de revistas | |
