Artículos de revistas
Consequences of Walker 256 tumor growth for the placental/fetal development in rats
Registro en:
Cancer Research Therapy & Control. Harwood Acad Publ Gmbh, v. 5, n. 4, n. 277, n. 283, 1998.
1064-0525
WOS:000076805500009
Autor
Gomes-Marcondes, MCC
Cury, L
Curi, R
Institución
Resumen
The association between pregnancy and cancer occurs in a small but clinically important group of patients. Studies about the influence of pregnancy on cancer prognosis have yielded conflicting results. Pregnancy has been reported to improve, worsen or not affect cancer prognosis. Metabolic adaptations to pregnancy are directed to ensure satisfactory growth and development of the fetus and to store energy for the new born and mother for immediate neonatal and lactation use. The effects of Walker 256 tumor growth and Walker 256 ascitic fluid intraperitoneal injection in adult pregnant Wistar rats and its consequences for fetal development were investigated. After mating, females were followed during 23 days. In non-pregnant and pregnant rats, the tumor implantation decreased daily food intake, nitrogen balance (NB) and carcass weight. Tumor weight was lower in pregnant than in the non-pregnant group. In addition, we observed that due to tumor growth there was a reduction of the fetal and placental weights. Fetal reabsorption was higher in pregnant tumor-bearing (25%) and in pregnant rats injected with ascitic fluid (25,3%) when compared with pregnant control group. Therefore, both tumour development and tumor ascitic fluid injected during pregnancy promote similar damaging effects in the placenta and fetal. These alterations were probably induced by substances produced by the host and cancer cells, which would directly or indirectly act on placental and/or fetal tissues. 5 4 277 283