Clinicopathological and immunohistochemical features of oral spindle cell carcinoma

dc.creatorRomanach, MJ
dc.creatorAzevedo, RS
dc.creatorCarlos, R
dc.creatorde Almeida, OP
dc.creatorPires, FR
dc.date2010
dc.dateAPR
dc.date2014-11-16T19:07:54Z
dc.date2015-11-26T16:24:42Z
dc.date2014-11-16T19:07:54Z
dc.date2015-11-26T16:24:42Z
dc.date.accessioned2018-03-28T23:05:34Z
dc.date.available2018-03-28T23:05:34Z
dc.identifierJournal Of Oral Pathology & Medicine. Wiley-blackwell Publishing, Inc, v. 39, n. 4, n. 335, n. 341, 2010.
dc.identifier0904-2512
dc.identifierWOS:000276247300008
dc.identifier10.1111/j.1600-0714.2009.00843.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/56087
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/56087
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/56087
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1268472
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionBackground: Oral spindle cell carcinoma (SpCC) is a rare variant of oral squamous cell carcinoma (SCC). The aims of this study were to compare the clinicopathologic and immunohistochemical features of oral SpCC with conventional oral SCC. Methods: Five cases of oral SpCC and 10 cases of oral SCC (five well-differentiated and five poorly differentiated) were evaluated through conventional hematoxylin and eosin staining and immunohistochemical reactions to cytokeratins (CK), vimentin, desmin, smooth muscle actin, muscle-specific actin, S-100 protein, epithelial membrane antigen (EMA), p53, and ki-67. Results: Oral SpCC showed predilection for males on their sixth decade of life, presenting clinically as painful infiltrative ulcers or ulcerated exophytic polypoid masses, preferably located on the alveolar mucosa. Mesenchymal markers were expressed in the spindle cell but not in the carcinomatous component of SpCC, and it was negative in all SCC. CKs AE1/AE3, 6, 14, and EMA were positive on both carcinomatous and spindle cell components of most SpCCs. These tumors also presented higher p53 and ki-67 expression and no CK 1 expression in contrast to well-differentiated SCC. Conclusion: Oral SpCC presented a different clinical profile than conventional SCC and histopathologic features and p53 and ki-67 expression closer to poorly differentiated SCC. Besides mesenchymal markers, CK AE1/AE3, 6, 14, and EMA expression on spindle cells may be useful as an adjunct on microscopical differential diagnosis of SpCC.
dc.description39
dc.description4
dc.description335
dc.description341
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherWiley-blackwell Publishing, Inc
dc.publisherMalden
dc.publisherEUA
dc.relationJournal Of Oral Pathology & Medicine
dc.relationJ. Oral Pathol. Med.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectcytokeratins
dc.subjectoral cancer
dc.subjectspindle cell carcinoma
dc.subjectsquamous cell carcinoma
dc.subjectSquamous Carcinoma
dc.subjectDifferential-diagnosis
dc.subjectSarcomatoid Carcinomas
dc.subjectHead
dc.subjectNeck
dc.subjectUtility
dc.subjectProgression
dc.subjectExpression
dc.subjectGingiva
dc.subjectMarkers
dc.titleClinicopathological and immunohistochemical features of oral spindle cell carcinoma
dc.typeArtículos de revistas


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