Involvement of temporomandibular joint P2X3 and P2X2/3 receptors in carrageenan-induced inflammatory hyperalgesia in rats

dc.creatorTeixeira, JM
dc.creatorOliveira, MCG
dc.creatorNociti, FH
dc.creatorClemente-Napimoga, JT
dc.creatorPelegrini-da-Silva, A
dc.creatorParada, CA
dc.creatorTambeli, CH
dc.date2010
dc.dateOCT 25
dc.date2014-11-17T02:23:29Z
dc.date2015-11-26T16:09:26Z
dc.date2014-11-17T02:23:29Z
dc.date2015-11-26T16:09:26Z
dc.date.accessioned2018-03-28T22:58:02Z
dc.date.available2018-03-28T22:58:02Z
dc.identifierEuropean Journal Of Pharmacology. Elsevier Science Bv, v. 645, n. 41699, n. 79, n. 85, 2010.
dc.identifier0014-2999
dc.identifierWOS:000282071300011
dc.identifier10.1016/j.ejphar.2010.06.008
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60677
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/60677
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60677
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1266619
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionThe aim of this study was to investigate the role of P2X3, P2X2/3 and P2X7 receptors in the development of TMJ hyperalgesia induced by carrageenan. We also investigated the expression of mRNA of P2X7 receptors in the trigeminal ganglia and the existence of functional P2X7 receptors in the rat's TMJ. The P2X1, P2X3 and P2X2/3 receptor antagonist TNP-ATP, but not the selective P2X7 receptor antagonist A-438079, significantly reduced carrageenan-induced TMJ inflammatory hyperalgesia. The qPCR assay showed that mRNA of P2X7 receptors are expressed in the trigeminal ganglia but this expression is not increased by the inflammation induced by carrageenan in the TMJ region. The P2X7 receptor agonist BzATP induced TMJ inflammatory hyperalgesia that was significantly reduced by pretreatment with dexamethasone. These results indicate that P2X3 and P2X2/3 but not P2X7 receptors are involved in carrageenan-induced TMJ inflammatory hyperalgesia. However, functional P2X7 receptors are expressed in the TMJ region. The activation of these receptors by BzATP sensitizes the primary afferent nociceptors in the TMJ through the previous release of inflammatory mediators. The findings of this study point out P2X3 and P2X2/3 receptors, but not P2X7 receptors, as potential targets for the development of new analgesic drugs to control TMJ inflammatory pain. (C) 2010 Elsevier B.V. All rights reserved.
dc.description645
dc.description41699
dc.description79
dc.description85
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationEuropean Journal Of Pharmacology
dc.relationEur. J. Pharmacol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectATP
dc.subjectP2X3 receptors
dc.subjectP2X2/3 receptors
dc.subjectP2X7 receptors
dc.subjectInflammatory hyperalgesia
dc.subjectTMJ
dc.subjectCarrageenan
dc.subjectDorsal-root Ganglia
dc.subjectSensory Neurons
dc.subjectNeuropathic Pain
dc.subjectP2x(7) Receptor
dc.subjectDown-regulation
dc.subjectKnockout Mice
dc.subjectFormalin Test
dc.subjectOxidized Atp
dc.subjectTmj Pain
dc.subjectExpression
dc.titleInvolvement of temporomandibular joint P2X3 and P2X2/3 receptors in carrageenan-induced inflammatory hyperalgesia in rats
dc.typeArtículos de revistas


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