Interaction between Serotoninergic-and beta-adrenergic Receptors Signaling Pathways in Rat Femoral Artery

dc.creatorDelbin, MA
dc.creatorSilva, AS
dc.creatorAntunes, E
dc.creatorZanesco, A
dc.date2012
dc.dateJAN
dc.date2014-07-30T14:33:49Z
dc.date2015-11-26T16:05:59Z
dc.date2014-07-30T14:33:49Z
dc.date2015-11-26T16:05:59Z
dc.date.accessioned2018-03-28T22:54:57Z
dc.date.available2018-03-28T22:54:57Z
dc.identifierArquivos Brasileiros De Cardiologia. Arquivos Brasileiros Cardiologia, v. 98, n. 1, n. 29, n. 34, 2012.
dc.identifier0066-782X
dc.identifierWOS:000300058100011
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60348
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60348
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1265841
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionBackground: Coronary heart disease has been widely studied in cardiovascular research. However, patients with peripheral artery disease (PAD) have worst outcomes compared to those with coronary artery disease. Therefore, pharmacological studies using femoral artery are highly relevant for a better understanding of the pathophysiologic responses of the PAD. Objective: The aim of this study was to evaluate the pharmacologic properties of the contractile and relaxing agents in rat femoral artery. Methods: Concentration response curves to the contractile phenylephrine (PE) and serotonin (5-HT) and the relaxing agents isoproterenol (ISO) and forskolin were obtained in isolated rat femoral artery. For relaxing responses, tissues were precontracted with PE or 5-HT. Results: The order rank potency in femoral artery was 5-HT > PE for contractile responses. In tissues precontracted with 5-HT, relaxing responses to isoproterenol was virtually abolished as compared to PE-contracted tissues. Forskolin, a stimulant of adenylyl cyclase, partially restored the relaxing response to ISO in 5-HT-precontracted tissues. Conclusion: An interaction between beta-adrenergic- and serotoninergic- receptors signaling pathway occurs in femoral artery. Moreover, this study provides a new model to study serotoninergic signaling pathway under normal and pathological conditions which can help understanding clinical outcomes in the PAD. (Arq Bras Cardiol 2012;98(1):29-34)
dc.description98
dc.description1
dc.description29
dc.description34
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherArquivos Brasileiros Cardiologia
dc.publisherRio De Janeiro
dc.publisherBrasil
dc.relationArquivos Brasileiros De Cardiologia
dc.relationArq. Bras. Cardiol.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectPeripheral arterial disease
dc.subjectfemoral artery/physiopathology
dc.subjectreceptors
dc.subjectadrenergic/alpha
dc.subjectreceptors
dc.subjectadrenergic/beta
dc.subjectreceptors
dc.subjectserotonin
dc.subject5-ht Receptors
dc.subjectCardiovascular-system
dc.subjectOcclusive Disease
dc.subjectDiversity
dc.subjectResponses
dc.subjectSubtypes
dc.subjectBiology
dc.titleInteraction between Serotoninergic-and beta-adrenergic Receptors Signaling Pathways in Rat Femoral Artery
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución